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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from authoritative database
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The toxicokinitic study of Prussian blue insoluble was performed on pig
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: Prussian blue
- IUPAC name: C.I.Pigment Blue 27
- Molecular formula: C6FeN6.4/3Fe
- Molecular weight (if other than submission substance): 859.23 g/mol
- Smiles : [CH-](#N)[Fe+2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)[CH-]#N.[CH-](#N)[Fe+2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)[CH-]#N.[CH-]
(#N)[Fe+2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)[CH-]#N.[Fe+3].[Fe+3].[Fe+3].[Fe+3]
- Inchi : 1S/18CN.7Fe/c18*1-2;;;;;;;/q18*-1;3*+2;4*+3
- Substance type: Inorganic
- Physical state: Solid powder (dark blue)
Radiolabelling:
yes
Species:
pig
Strain:
not specified
Details on species / strain selection:
No data available
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Route of administration:
oral: capsule
Vehicle:
not specified
Details on exposure:
No data available
Duration and frequency of treatment / exposure:
No data available
Dose / conc.:
40 mg/kg bw/day (nominal)
No. of animals per sex per dose / concentration:
38
Control animals:
not specified
Positive control reference chemical:
No data available
Details on study design:
No data available
Details on dosing and sampling:
No data available
Statistics:
No data available
Preliminary studies:
No data available
Type:
excretion
Results:
99% of the administered Prussian blue dose was excreted unchanged in feces
Details on absorption:
Test material poorly absorb
Details on distribution in tissues:
No data available
Transfer type:
other: No data available
Observation:
not determined
Details on excretion:
99% of the administered Prussian blue dose was excreted unchanged in feces
Test no.:
#1
Toxicokinetic parameters:
other: 99% excreted unchanged in feces
Metabolites identified:
not specified
Details on metabolites:
No data available
Bioaccessibility (or Bioavailability) testing results:
No data available
Conclusions:
The toxicokinitic study of Prussian blue insoluble was performed on pig. 38 animals were used. A single dose of 40 mg labelled Prussian blue insoluble were adminstered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces, therefore is likely to have low bio-accumulation potential
Executive summary:

The toxicokinitic study of Prussian blue insoluble was performed on pig. 38 animals were used. A single dose of 40 mg labelled Prussian blue insoluble were administered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces,therefore is likely to have low bio-accumulation potential

Description of key information

The bio-accumulation potential of the target chemical Prussian blue insoluble (14038-43-8).In-vivo studies in pig .A single dose of 40 mg labelled Prussian blue insoluble were administered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces, Therefore, it has been concluded that the target chemical is also unlikely to bio-accumulate in-vivo.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
1

Additional information

The bio-accumulation potential of the target chemical Prussian blue insoluble (14038-43-8).In-vivo studies in pig .A single dose of 40 mg labelled Prussian blue insoluble were administered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces, Therefore, it has been concluded that the target chemical is also unlikely to bio-accumulate in-vivo.