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EC number: 237-725-9 | CAS number: 13945-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance.
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 21 d
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- reproduction
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 95912-86-0, BASF, 2013, D. magna, 21 d
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- reproduction
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 135800-37-2, BASF, 1998, D. magna, 21 d
- Conclusions:
- The key values retained for the long-term toxicity of the target substance to aquatic invertebrates are a NOELR (21 d) of ≥ 10 mg/L and a NOEC (21 d) of ≥ 1 mg/L (WAF) based on the available experimental studies for two structurally and chemically closely related source substances (nominal, OECD 211, D. magna); read-across
Reference
Description of key information
No effects up to the limit of water solubility (OECD 211, D. magna); read-across
Key value for chemical safety assessment
Additional information
There is no study available, in which the long-term toxicity of lauryl laurate (CAS 13945-76-1) to aquatic invertebrates was investigated. Therefore, read-across to the two structurally related source substances fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) and fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2)was conductedin accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid and alcohol components and are therefore considered suitable representatives for the assessment of the long-term toxicity of the target substance to aquatic invertebrates. A detailed justification of the analogue approach is provided in IUCLID section 13.
Both the available studies were conducted according to GLP.
In the study with the source substance fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0), a semi-static limit test was performed according to OECD 211, in which Daphnia magna was exposed to a water accommodated fraction with a nominal loading rate of 10 mg/L for 21 d. A chemical analysis of the test item concentrations was not possible because no suitable analytical method was found to detect the poorly soluble substance. After 21 d, no effects on reproduction of D. magna were observed up to the limit of water solubility (< 0.05 mg/L), resulting in a NOELR (21 d) ≥ 10 mg/L. Based on this result it can be concluded that fatty acids, C8-10, C12-18-alkyl esters does not cause chronic toxicological effects on aquatic invertebrates up to the limit of water solubility.
In the study with the source substance fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2), a semi-static test was performed according to OECD 202, part II (1984), in which D. magna was exposed to filtered test solutions with nominal test item loading rates of 1 and 100 mg/L for 21 d.
After 21 d, no effects on mortality and reproduction was observed in the filtered solution of 1 mg/L. However, a significant reduction of reproduction was recorded in the filtered solution of 100 mg/L. The authors supposed that the observed effects in the 100 mg/L filtered test solution were either due to a better water soluble by-compound (e.g. a short chain fatty acid ester) or, less likely, due to a toxic impurity. Therefore, a NOEC for reproduction (21 d) of ≥ 1 mg/L (nominal) was reported.
Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile as the selected source substances. Therefore, it can be concluded that the target substance lauryl laurate (CAS 13945-76-1) does not cause long-term toxicological effects on aquatic invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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