Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-075-6 | CAS number: 13598-65-7
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 97.2 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. As no data on effects of repeated inhalation exposure to ammonium perrhenate in humans or laboratory animals are available, route-to-route extrapolation to calculate a DNEL for such effects from a reliable Repeated dose toxicity with Reproductive/Developmental toxicity screening test (OECD TG422) by the oral route in rats was considered a suitable alternative (no high first-pass metabolism has been reported or is expected).
- AF for dose response relationship:
- 1
- Justification:
- Default AF; human health relevant NOAEL from well-conducted 28-day dietary study. Effects at 330 mg/kg bw/day (increase in thyroid weight in both sexes, and a slight increased incidence of ploughing and excess salivation in males) were not considered severe
- AF for differences in duration of exposure:
- 6
- Justification:
- Default AF for subacute (28-day) to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default ECHA AF for rats for toxicokinetic differences in metabolic rate (allometric scaling); already considered in modification of starting point above
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 5
- Justification:
- Default ECHA AF for (healthy) worker
- AF for the quality of the whole database:
- 1
- Justification:
- Default AF; the human health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 110 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. As no data on effects of repeated dermal exposure to ammonium perrhenate in humans or laboratory animals are available, route-to-route extrapolation to calculate a DNEL for such effects from a reliable repeated dose oral toxicity study in rats was considered a suitable alternative (no high first-pass metabolism has been reported or is expected).
- AF for dose response relationship:
- 1
- Justification:
- Default AF; human health relevant NOAEL from well-conducted 28-day dietary study. Effects at 330 mg/kg bw/day (increase in thyroid weight in both sexes, and a slight increased incidence of ploughing and excess salivation in males) were not considered severe
- AF for differences in duration of exposure:
- 6
- Justification:
- Default AF for subacute (28-day) to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default ECHA AF for rats for toxicokinetic differences in metabolic rate (allometric scaling)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 5
- Justification:
- Default ECHA AF for (healthy) worker
- AF for the quality of the whole database:
- 1
- Justification:
- Default AF; the human health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 47.8 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- In the absence of any data to the contrary, the same bioavailability is assumed for humans and laboratory animals. As no data on effects of repeated inhalation exposure to ammonium perrhenate in humans or laboratory animals are available, route-to-route extrapolation to calculate a DNEL for such effects from the repeated dose oral toxicity study was considered a suitable alternative (no high first-pass metabolism has been reported or is expected).
- AF for dose response relationship:
- 1
- Justification:
- Default AF; human health relevant NOAEL from well-conducted 28-day dietary study. Effects at 330 mg/kg bw/day (increase in thyroid weight in both sexes, and a slight increased incidence of ploughing and excess salivation in males) were not considered severe
- AF for differences in duration of exposure:
- 6
- Justification:
- Default AF for subacute (28-day) to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default ECHA AF for rats for toxicokinetic differences in metabolic rate (allometric scaling); already considered in modification of starting point above
- AF for other interspecies differences:
- 2.5
- Justification:
- Default ECHA AF for remaining toxicokinetic differences (not related to metabolic rate) and toxicodynamic differences
- AF for intraspecies differences:
- 10
- Justification:
- Default ECHA AF for general population (including children and the elderly)
- AF for the quality of the whole database:
- 1
- Justification:
- Default AF; the human health effects data are reliable and consistent, the available information meets the tonnage driven data requirements, and confidence in the database is high
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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