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EC number: 236-102-9 | CAS number: 13162-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
There was no functional or morphological evidence of neurotoxicity in a 90-day repeated dose inhalation study in rats with neurofunctional testing and neuropathology (BASF AG, 1995).
Key value for chemical safety assessment
Additional information
In the key study that was performed according to OECD guideline 413 with additional neurotoxicity testing following EPA test guideline (EPA 1985/87), 15 male and 15 female Wistar rats per test group were exposed to vapors of Vinylformamide (VFA) for 6 hours per working day for 103 days (65 exposures). The target concentrations of treatment groups were 10, 50 and 250 mg/m³ (3,4 ; 17 and 86 ppm). A concurrent control group was exposed to clean air. Clinical examination was performed once each working day during preflow period and on post exposure day (day 103). On exposure days findings were recorded before, during and after exposure. Body weight of the animals was determined weekly. Ophthalmology was carried out prior to and at the end of exposure period. Functional observational batteries and motor activity measurements were performed in 10 animals/sex and test group once before start of the exposure period and three times during the exposure period in about monthly intervals. Hematological and clinicochemical examination of numerous parameters was performed in 10 animals/ sex at the end of exposure period, including GSH and gamma-GT levels in liver homogenate. A complete necropsy including weighing of selected organs and gross pathological evaluation was performed in ten animals per sex. Histopathology was performed on several organs and tissues in these animals as required by the corresponding testing guidelines. Five animals per sex were sacrificed by perfusion fixation. These animals underwent neuropathological examinations. There was no functional or morphological evidence of neurotoxicity (BASF AG, 1995)
Justification for classification or non-classification
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
no classification required
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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