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EC number: 233-143-4 | CAS number: 10043-84-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
On the basis of available studies for the closely related chemicals, the weight of evidence approach was applied to assess the dermal irritation potential for target substance.
Manganese(2+) bis(phosphinate) was estimated to be not irritating to skin.
Eye Irritation:
On the basis of available studies for the closely related chemicals, the weight of evidence approach was applied to assess the ocular irritation potential for manganese(2+) bis(phosphinate).
Manganese(2+) bis(phosphinate) was estimated to be irritating to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Weight of evidence approach based on similar chemicals
- Justification for type of information:
- Weight of evidence approach based on similar chemicals
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Weight of evidence based on similar chemicals
- Principles of method if other than guideline:
- The weight of evidence report has been prepared based on the read across substances identified based on structural and functional similarity to assess the dermal irritation potential of manganese(2+) bis(phosphinate)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: manganese(2+) bis(phosphinate)
- Molecular formula: H3O2P1/2Mn
- Molecular weight: 184.9136 g/mol
- Smiles notation: [Mn+2].[O-]P=O.[O-]P=O
- InChl: 1S/Mn.2H3O2P/c;2*1-3-2/h;2*3H2,(H,1,2)/q+2;;/p-2
- Substance type: Inorganic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- male
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml moistened with water
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48 and 72 hours
- Number of animals:
- 3
- Details on study design:
- The study is based on weight of evidence approach from the read across values
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation observed
- Interpretation of results:
- other: not irritating
- Conclusions:
- On the basis of available studies for the closely related chemicals, the weight of evidence approach was applied to assess the dermal irritation potential for target substance.
Manganese(2+) bis(phosphinate) was estimated to be not irritating to skin. - Executive summary:
Based on the available studies for closely related chemicals, weight of evidence approach was applied to assess the dermal irritation potential of manganese(2+) bis(phosphinate).
The dermal irritation potential of the test chemical was assessed in rabbits according to OECD 404 Guidelines.0.5 g of the test chemical (mixed with 0.5 ml of distilled water to create a paste) was applied to the shaven skin of 3 male New Zealand White rabbits under semi-occlusive conditions for 4 hours. The test sites were observed for erythema and edema 24 hours post exposure till 7 days.
One rabbit showed erythema (score = 2) and oedema (score = 1) at 24 hours postexposure, both of which were reversed by seven days post-exposure.
Since the effects were reversible in 7 days, hence the test chemical was considered to be not irritating to skin.
This is supported by the results of similar study conducted according to OECD 404 Guidelines for other closely related chemical.0.5 g of the test chemical (mixed with 0.5 ml of distilled water to create a paste) was applied to the shaven skin of 3 male New Zealand White rabbits under semi-occlusive conditions for 4 hours.
The rabbits were observed 24, 48 and 72 hours post exposure.
No signs of irritation were observed after 72 hours of observation.
Hence, the test chemical was considered to be not irritating to skin.
Based on the available data for the closely related chemicals and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar mannerthat of the read across substances. Therefore,Manganese(2+) bis(phosphinate)was estimated to be not irritating to skin and it can be further classified under the category “Not Classified” as per CLP regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Weight of evidence based on similar chemicals
- Justification for type of information:
- Weight of evidence based on similar chemicals
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Weight of evidence based on similar chemicals
- Principles of method if other than guideline:
- The weight of evidence report has been prepared based on the read across substances identified based on structural and functional similarity to assess the ocular irritation of manganese(2+) bis(phosphinate)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: manganese(2+) bis(phosphinate)
- Molecular formula: H3O2P1/2Mn
- Molecular weight: 184.9136 g/mol
- Smiles notation: [Mn+2].[O-]P=O.[O-]P=O
- InChl: 1S/Mn.2H3O2P/c;2*1-3-2/h;2*3H2,(H,1,2)/q+2;;/p-2
- Substance type: Inorganic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- sex: male/ female
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 1. 24,48, 72 hours till 10 days
2. 24,48, 72 hours till 10 days - Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 1. 3 female
2. 2 male - Details on study design:
- The study is based on weight of evidence approach from the read across values
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 21 d
- Reversibility:
- not fully reversible within: 21 Days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Signs of irritation observed
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- On the basis of available studies for the closely related chemicals the weight of evidence approach was applied to assess the ocular irritation potential for manganese(2+) bis(phosphinate).
Manganese(2+) bis(phosphinate) was estimated to be irritating to eyes. - Executive summary:
Based on the available studies for closely related chemicals, weight of evidence approach was applied to assess the ocular irritation potential of manganese(2+) bis(phosphinate).
The ocular irritation potential of the test chemical was assessed in rabbits according to OECD 405 Guidelines. 100 mg of undiluted test chemical was instilled in the eyes of 3 female New Zealand White rabbits and observed for signs of irritation till 10 days.It was observed that corneal opacity was minimal (average 0.33/4 for all animals over the 24, 48 and 72 hour time-points), but that it was not fully reversed within 72 hours in one rabbit. There was no iritis in any rabbit over the duration of the study. The average score for conjunctival redness was 3/3 for all animals over the 24, 48 and 72 hour time-points, but this was fully reversible within 10 days. The average score for chemosis was 3/4 for all animals over the 24, 48 and 72 hour time-points and chemosis was not fully reversed within seven days in one rabbit.
Since the most of the effects were not reversible by 10 days, the test chemical can be considered to be irritating to eyes.
This is supported by the results of similar study conducted according to OECD 405 Guidelines for other closely related chemical. 100 mg of undiluted test chemical was instilled in the eyes of 2 male New Zealand White rabbits and observed for signs of irritation till 21 days. The maximum mean total score was 53/110 at 48 hours post-exposure, and corneal and conjunctival lesions were not reversible by 21 days post-exposure. Since the most of the effects were not reversible by 21 days, the test chemical can be considered to be severely irritating to eyes.
Based on the available data for the closely related chemicals and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar mannerthat of the read across substances. Therefore,Manganese(2+) bis(phosphinate)was estimated to be irritating to eyes and it can be further classified under the category “Category 2” as per CLP regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
Based on the available studies for closely related chemicals, weight of evidence approach was applied to assess the dermal irritation potential of manganese(2+) bis(phosphinate).
The dermal irritation potential of the test chemical was assessed in rabbits according to OECD 404 Guidelines.0.5 g of the test chemical (mixed with 0.5 ml of distilled water to create a paste) was applied to the shaven skin of 3 male New Zealand White rabbits under semi-occlusive conditions for 4 hours. The test sites were observed for erythema and edema 24 hours post exposure till 7 days.
One rabbit showed erythema (score = 2) and oedema (score = 1) at 24 hours postexposure, both of which were reversed by seven days post-exposure.
Since the effects were reversible in 7 days, hence the test chemical was considered to be not irritating to skin.
This is supported by the results of similar study conducted according to OECD 404 Guidelines for other closely related chemical. .0.5 g of the test chemical (mixed with 0.5 ml of distilled water to create a paste) was applied to the shaven skin of 3 male New Zealand White rabbits under semi-occlusive conditions for 4 hours.
The rabbits were observed 24, 48 and 72 hours post exposure.
No signs of irritation were observed after 72 hours of observation.
Hence, the test chemical was considered to be not irritating to skin.
Based on the available data for the closely related chemicals and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar mannerthat of the read across substances. Therefore,Manganese(2+) bis(phosphinate)was estimated to be not irritating to skin and it can be further classified under the category “Not Classified” as per CLP regulation.
Eye Irritation:
Based on the available studies for closely related chemicals, weight of evidence approach was applied to assess the ocular irritation potential of manganese(2+) bis(phosphinate).
The ocular irritation potential of the test chemical was assessed in rabbits according to OECD 405 Guidelines. 100 mg of undiluted test chemical was instilled in the eyes of 3 female New Zealand White rabbits and observed for signs of irritation till 10 days.It was observed that corneal opacity was minimal (average 0.33/4 for all animals over the 24, 48 and 72 hour time-points), but that it was not fully reversed within 72 hours in one rabbit. There was no iritis in any rabbit over the duration of the study. The average score for conjunctival redness was 3/3 for all animals over the 24, 48 and 72 hour time-points, but this was fully reversible within 10 days. The average score for chemosis was 3/4 for all animals over the 24, 48 and 72 hour time-points and chemosis was not fully reversed within seven days in one rabbit.
Since the most of the effects were not reversible by 10 days, the test chemical can be considered to be irritating to eyes.
This is supported by the results of similar study conducted according to OECD 405 Guidelines for other closely related chemical. 100 mg of undiluted test chemical was instilled in the eyes of 2 male New Zealand White rabbits and observed for signs of irritation till 21 days. The maximum mean total score was 53/110 at 48 hours post-exposure, and corneal and conjunctival lesions were not reversible by 21 days post-exposure. Since the most of the effects were not reversible by 21 days, the test chemical can be considered to be severely irritating to eyes.
Based on the available data for the closely related chemicals and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar mannerthat of the read across substances. Therefore,Manganese(2+) bis(phosphinate)was estimated to be irritating to eyes and it can be further classified under the category “Category 2” as per CLP regulation.
Justification for classification or non-classification
The results of the experimental studies from the closely related substances indicate a possibility that manganese(2+) bis(phosphinate) can be not irritating to skin and but may be irritating to eyes.
Hence by applying the weight of evidence approach, manganese(2+) bis(phosphinate) can be considered to be not irritating to skin and irritating to eyes. It can be classified under the category “Not Classified” for skin irritation and “Category 2” for eye irritation as per CLP regulation.
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