Registration Dossier
Registration Dossier
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EC number: 231-974-7 | CAS number: 7783-00-8
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish, juvenile growth test
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed study. Effect concentrations based on measured selenium concentrations.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of sodium selenite to rainbow trout fry
- Author:
- Hunn JB, Hamilton SJ, Buckler DR
- Year:
- 1 987
- Bibliographic source:
- Water Research 21, 233-238
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Salmo gairdneri (rainbow trout) fry were exposed to waterborne selenium as sodium selenite for a period of 90 days under flow-through conditions using a proportional diluter. Five concentrations and a control were tested. Test concentrations were analytically verified.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium selenite
- EC Number:
- 233-267-9
- EC Name:
- Sodium selenite
- Cas Number:
- 10102-18-8
- Molecular formula:
- H2O3Se.2Na
- IUPAC Name:
- disodium selenite
- Details on test material:
- - Name: sodium selenite
- Analytical purity: 98%
- Source: Sigma Chemical Company
- No further information stated
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from all treatments, frequency not stated.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- see test conditions
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Source: no data
- Length at study initiation: 21.7 mm
- Weight at study initiation: 75 mg
- Fish were fed a commercial diet supplemented with live nauplii of brine shrimp (ad libitum) for the first 30 days of the study.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 90 d
Test conditions
- Hardness:
- 272 mg CaCO3/L
- Test temperature:
- 12 +/- 1 °C
- pH:
- 7.4
- Dissolved oxygen:
- 237 mg CaCO3/L
- Nominal and measured concentrations:
- Measured concentrations: control, 7.8, 12.4, 21.0, 47.2 and 99.5 ug/L
- Details on test conditions:
- TEST SYSTEM
- Type of flow-through: proportional diluter
- No. of organisms per vessel: 20 fry
- No. of vessels per concentration (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: well water
- Dilution water parameters: Well water was characterized by pH 7.4, alkalinity 237 mg/L as CaCO3 , hardness 272 mg/L as CaCO3 and selenium < 0.4 ug/L.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality, length and body weight
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 90 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 21 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- mortality
- Duration:
- 90 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 47.2 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- mortality
- Duration:
- 90 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 47.2 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- length
- Remarks:
- and body weight
- Duration:
- 90 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 99.5 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- length
- Remarks:
- and body weight
- Reported statistics and error estimates:
- Split plot in time analysis of variance + Least Significant Difference test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Reliable (Klimisch 2) study in which Salmo gairdneri (rainbow trout) fry were exposed to selenium as sodium selenite for a period of 90 days under flow-through conditions using a proportional diluter. Five concentrations and a control were tested. Test concentrations were analytically verified. The most sensitive endpoint investigated was mortality with a 90-day NOEC and LOEC of 21 and 47.2 µg Se/L, respectively.
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