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EC number: 230-589-1 | CAS number: 7209-38-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-10-21 - 2017-01-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N,N'-bis(3-aminopropyl)piperazine
- EC Number:
- 230-589-1
- EC Name:
- N,N'-bis(3-aminopropyl)piperazine
- Cas Number:
- 7209-38-3
- Molecular formula:
- C10H24N4
- IUPAC Name:
- 3-[4-(3-aminopropyl)piperazin-1-yl]propan-1-amine
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Activated sludge from the municipal sewage treatment plant , 31137 Hildesheim, Germany. The activated sludge from the sewage treatment plant Hildesheim is well suited as it receives predominantly municipal sewage and hardly any industrial chemical waste.
The activated sludge was washed twice with chlorine free tap water. Afterwards the settled sludge was resuspended in mineral salt medium and was maintained in aerobic condition by aeration for two hours. Thereafter the sludge was homogenized with a blender. After sedimentation the supernatant was decanted and maintained under aeration with CO2-free air for 6 days. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 25 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Both two test item replicates did not reach the 10% biodegradtion level (beginnin of biodegradation) within the 28 days test period. The mean biodegradation was 0%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Both two test item replicates did not reach the 10% biodegradtion level (beginnin of biodegradation) within the 28 days test period. The mean biodegradation was 0%. The test item is classified a not readily biodegradable within the 28 days period of the study.
- Executive summary:
The ready biodegradability of the test item N,N`-bis(3-aminopropyl)piperazine was determined with non-adapted activated sludge in the Manometric Respirometry Test for a period of 28 days. The study was conducted with the definite exposure phase from 2016 -11 -16 to 2016 -12 -14, according to OECD guideline 301 F at the test facility. The test item concentration selected as appropriate was 25.0 mg/L, corresponding to a ThOD of 52.0 mg O2/L (83.8 mg O2/L with nitrification) per test vessel. The oxygen was depleted by the respiration of bacteria and the degradation was followed by measuring the oxygen concentration. The biodegradation rate is therefore expressed as the percentage BOD (biological oxygen demand) and was calculated for each study day.
The mean oxygen depletion in the inoculum control was 9.60 mg O2/L on day 28.
In order to check the activity of the test system sodium benzoate was used as functional control. The pass level > 60% was reached on day 3. The biodegradation reached a maximum of 98% degradation on day 27.
In the toxicity control containing both test and reference item 51% degradation occurred within 14 days. After 28 days the biodegradation reached 54%. The degradation of the reference item was not inhibited by the test item.
Both test item replicates did not reach the 10% level (beginning of biodegradation) within the 28 days period of the study. The mean biodegradation on day 28 was 0%.
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