Registration Dossier
Registration Dossier
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EC number: 221-639-3 | CAS number: 3173-53-3
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- purity not specified
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.7
- Temp.:
- 25 °C
- pH:
- 6.8
Any other information on results incl. tables
In order to ensure a stable performance of the HPLC column, the column temperature was set to 40°C. The reference Pow-values in the OECD guideline presumably refer to 25°C. Even though the column temperature was 40°C, this temperature has no influence on the result of the determination. Therefore the Pow -value of the test item determined within this study also refers to 25 °C.
Contrary to the calibration substances, the test item Cyclohexylamine could only be detected with MSD instead of DAD. A significant influence on the retention time can be excluded as was seen in study 2010/0031/02 (Determination of the Adsorption Coefficient). The retention time of a reference substance only varied around 0.06 min between the two detection methods. No significant influence on the outcome of the study was assumed.
Applicant's summary and conclusion
- Executive summary:
Cyclohexylamine has a measured log Kow of 3.7 at a temperature of 25 °C and a pH value of 6.8. (Currenta, 2010).
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