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EC number: 214-633-7 | CAS number: 1173-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Dec 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3β,21-dihydroxy-16α-methylpregn-5-en-20-one 21-acetate
- EC Number:
- 214-633-7
- EC Name:
- 3β,21-dihydroxy-16α-methylpregn-5-en-20-one 21-acetate
- Cas Number:
- 1173-09-7
- Molecular formula:
- C24H36O4
- IUPAC Name:
- 2-[(1S,2R,3aS,3bS,7S,9aR,9bS,11aS)-7-hydroxy-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 16Alpha-Methyl-Acetoxypregnenolon
- Lot/batch No.: 14415018
- Analytical purity: 98,9%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1.8 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Table 1: Cumulative immobilization
Cumulative immobilization | |||
Concentration of | Total no. of Daphnia | Immobilized Daphnia | |
ZK 29211 | 24 hours | 48 hours | |
0 mg/l | 20 | 0 | 0 |
1,8 mg/I | 20 | 0 | 0 |
Table 2: Concentration analysis by TOC measurement
Test compound | Day 1 | Day3 | |
Control vessel | 1.6 mg/L TOC | 2.9 mg/L TOC | |
ZK 29211 (test vessel) | 3.2 mg/L TOC | 4.0 mg/LTOC | |
Test vessel -control vessel | 1.5 mg/L TOC | 1.2 mg/L TOC | |
ZK 29211 | 2.1 mg/L | 1.6 mg/L | |
Mean value | 1.8 mg/L |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50/48 hours of ZK 29211 to Daphnia magna is higher than a saturated solution
(1.8 mg/L) which was prepared using a suspension corresponding to 100 mg/L nominal loading. - Executive summary:
The purpose of this study was to determine the acute toxicity (immobilization, ECso/48 hours)
of 16Alpha-Methyl-Acetoxypregnenolon (ZK 29211) with Daphnia magna in a limit test in order to evaluate the aquatic toxicity.
The study was conducted in agreement with the guideline of the OECD, no. 202.
20 Daphnia were used for the test solution of ZK 29211 and 20 for the dilution water control.
The Daphnia were exposed to the test solution and the dilution water for aperiod of 48 hours
under static conditions. Immobilization was recorded at 24 and 48 hours.
The nominalloading of the test solution was 100 mg/L. For the preparation of the test solution,
a suspension corresponding to a nominal concentration of 100 mg/L was filtered through a
glassfibre filter.
The organic carbon concentration of the test solution was analysed with a TOC-analyser at
o and 48 hours and the substance concentration was calculated according to the structural
formula. The concentration of the filtered solution was 1.6-2.1 mg/L (mean: 1.8 mg/L).
No immobilized Daphnia were observed in the control or in the test solution.
The EC50/48 hours of ZK 29211 to Daphnia magna is higher than a saturated solution
(1.8 mg/L) which was prepared using a suspension corresponding to 100 mg/I nominal loading.
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