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Diss Factsheets
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EC number: 214-527-0 | CAS number: 1141-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Bioaccumulation Study of Chemicals" described in "About Test Methods for New Chemical Substances" (Kanpogyo Notification No. 5, Yakuhatsu Notification No. 615, and 49 Kikyoku Notification No. 392)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No.of test material: K-599 - Radiolabelling:
- no
- Details on sampling:
- - Sampling intervals/frequency for test organisms: Samples were taken in duplicate 2, 3, 4 and 6 weeks after test start
- Sampling intervals/frequency for test medium samples: Samples were taken in duplicate twice weekly
- Sample storage conditions before analysis: Analysis of the samples was done immediately after sampling
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods): - Vehicle:
- not specified
- Details on preparation of test solutions, spiked fish food or sediment:
- PREPARATION AND APPLICATION OF TEST SOLUTION
Test substance was dissolved in an aqueous solution adjusted to pH 12 with sodium hydroxide. After this, the solution was re-adjusted to pH 7 with hydrochloric acid and filled up with demineralized water to obtain a stock solution of 100 mg/L. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Strain: TFC 840321
- Source: Yatsushiro City, Kumamoto Prefecture Kitamura nursery school
- Age at study initiation: 6 weeks
- Length at study initiation: 9.8 cm (average body lenth)
- Weight at study initiation: 22.42 g (mean body weight)
- Lipid content at test initiation: 4.1% (average lipid content)
- Description of housing/holding area: 100mL glass aquarium
- Feeding during test
- Food type: Carp diet (manufactured by Nippon Blended Manufacturing Co. Ltd.)
- Amount: Approximately 2% equivalent weight of fish weight
- Frequency: Twice a day - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Test temperature:
- 25 +/- 2°C
- Dissolved oxygen:
- 6.5-7.5 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 L glass aquarium
- Renewal rate of test solution (frequency/flow rate): 582 L/day
- No. of organisms per vessel: 20 - Nominal and measured concentrations:
- 100 µg/L (first group)
10 µg/L (second group) - Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- The bioconcentration factor (BCF) was calculated according to the following formula:
BCF = (Cfn-Cfb)/Cwn
Cfn: Concentration of the test substance in the sample fish analysis sample
Cwn: Averages of measured concentrations by test water analyzes conducted up to weekday
Cfb: Concentration of the test substance in the fish body (released) in empty test - Conc. / dose:
- 100 µg/L
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- 0.6 L/kg
- Basis:
- whole body w.w.
- Key result
- Conc. / dose:
- 10 µg/L
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- >= 5.2 - <= 7.7 L/kg
- Basis:
- whole body w.w.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The maximum BCF of the test substance to the carp was 7.7 L/kg, corresponding to a log BCF of 0.89.
Reference
Description of key information
Key value for chemical safety assessment
- BCF (aquatic species):
- 7.7 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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