Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-834-7 | CAS number: 1025-15-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
skin irritation (OECD 404): not classified
eye irritation (OECD 405): not classified
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
Skin irritation by triallyl isocyanurate was evaluated in a GLP study according to OECD guideline 404 (2003-0178-DGT). 0.5 mL test item was applied to the shaved skin of 3 Himalayan rabbits under semi-occlusive conditions for 4 hours. In one animal erythema of grade 1 were noted at the 24, 48 and 72 h and 4 day reading time point. No further skin reactions were noted in any of the animals. Thus, the mean scores out of all 3 animals over 24, 48 and 72 h were 0.3 and 0 for erythema and edema, respectively. No systemic toxicological reactions were noted.
Under the conditions of this GLP guideline study triallyl isocyanurate is considered not to be irritating to skin.
In a non-guideline study with one single rabbit, repeated applications of 15% triallyl isocyanurate for 3 consecutive days on the abraded abdomen as well as the response to 10 applications of 15% triallyl isocyanurate over 14 days to the ear and intact abdomen were examined (TSCA Section 8(e), Doc-ID 88-920002607). Readings were performed on each application day and thereafter on day 15 and 21 using a 6-grade scoring system for hyperemia, edema, necrosis, exfoliation, hair loss, scab and scar. Slight hyperemia (grade 3) was observed after test substance application on the intact and abraded abdomen. However this skin response was reversible after treatment had stopped. Slight exfoliation (grade 3) was noted on the intact and abraded abdomen starting from day 7. On the ear slight hyperemia (grade 3) was observed on day 9 as well as slight exfoliation (grade 3) on day 7, 14 and 21. In conclusion, repeated prolonged exposures to triallyl isocyanurate may cause slight irritation.
Eye
Eye irritation by triallyl isocyanuarate was examined in a GLP study according to OECD guideline 405 (2003-0180-DGT). 0.1 mL test item was instilled into the the right eyes of 3 Himalayan rabbits (no washout). The untreated left eye of each animal served as control. The eye reactions were examined 1, 24, 48 and 72 h after application and resulted in mean scores of 0 for corneal opacity, iris, conjunctival redness and chemosis, respectively. The fluorescein test 24 h after test item instillation revealed no pathological findings. There were no systemic intolerance reactions.
Under the conditions of this study, triallyl isocyanurate is considered not to be an irritant to eyes.
In a poorly reported non-guideline study, triallyl isocyanurate was instilled in both eyes of one male rabbit (TSCA Section 8(e), Doc-ID 88-920002607). The right eye was rinsed after 30 sec and the left eye was washed after the first fluorescein staining of the eye at the 1 h reading time point. Further readings were performed immediately after instillation as well as 24 h, 48 h and 7 days after test item application using a 6-grade scoring system with grade 1 indicating no effect and grade 6 representing severe reactions.
Immediately after test substance application a slight conjunctivae response (grade 3) was observed in both eyes. At the 1 h reading time point, pupils did not react properly. In addition, the degree of of constrictions was much less than normal. The slight conjunctivae response (grade 3) observed immediately after treatment was still present after 1 h in both eyes and persisted in the right eye to 24 h after treatment. At the 48 h reading time point the pupils were normal and no more response on conjunctivae was noted in the right eye. No corneal and iris response was observed at any reading time point. In conclusion, under the conditions of this non-guideline study slight transient conjunctival irritation was observed.
Justification for classification or non-classification
The available data on skin and eye irritation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.