Registration Dossier
Registration Dossier
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EC number: 213-600-4 | CAS number: 993-00-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No data are available for Chloro(methyl)silane. A 96-hour LC50 of 271 mg/L has however been determined for the effects of a read-across substance, Trimethylsilanol (CAS 1066-40-6), on mortality of Oncorhynchus mykiss. A NOEC of 128 mg/L has been determined in the same test. A 96-hour LC50 value of >126 mg/L and NOEC of ≥126 mg/L have been determined for the effects of a second read-across substance, Dimethylsilanediol, 1066-42-8, on mortality of O. mykiss. The results of the test with Trimethylsilanol (CAS 1066-40-6) have been selected as the key results because they are definitive values.
Key value for chemical safety assessment
Additional information
No test data for short-term toxicity to fish are available for Chloro(methyl)silane. However reliable data for short-term toxicity to fish are available for the related substances Dimethylsilanediol, 1066-42-8, and Trimethylsilanol, 1066-40-6. The hydrolysis half-life of Chloro(methyl)silane indicates that, under conditions relevant to the acute fish toxicity test, hydrolysis to methylsilanol and hydrogen chloride will occur. The properties of hydrogen chloride are well characterised and are discussed in the CSR. Its effects on aquatic organisms are limited to those that result from changes to pH in unbuffered media. Read-across from trimethylsilanol and dimethylsilanediol to methylsilanol is appropriate because all are small molecule alkylsilanols containing Me-Si and HO-Si groups; their properties are expected to be similar.
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