Registration Dossier
Registration Dossier
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EC number: 212-449-1 | CAS number: 818-08-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance does not dissolve in water or in octanol
Reference
Description of key information
No determination was performed using the shake-flask method, designed to be compatible Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 for the following reasons:
- A visual assessment of solubility in both water and n-octanol was found to be less than 1 mg/l.
- The partition coefficient determination using the HPLC method, Method 117 of the OECD Guidelines for Testing of Chemicals, was unsuitable since organometallic materials are known to react with HPLC columns.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.33
- at the temperature of:
- 20 °C
Additional information
It was not technically feasible to conduct this endpoint based on the information from the following studies:
A data waiver was used to fulfil this endpoint based on the information given in the Butler & White (2010) study. A reliability rating of 1 was assigned to this study, according to the criteria of Klimisch, 1997 as the study was conducted to recognised guidelines, however due to the nature of the substance, a Pow value could not be obtained.
A calculated estimate of Log Kow = 5.33 at 20.0 C has been used for the CSA due to the absence of any other suitable data. Although a calculation for a Log Pow can be derived it is not considered valid for this class of substance and the registrant also considers it justified to omit a Robust Study Summary for this data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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