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EC number: 209-608-2 | CAS number: 587-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation:
The substance sodium
3-[(4-anilinophenyl)diazenyl]benzenesulfonate was observed to show
positive reactions in Human patch test for skin sensitization.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate the skin sensitizing potential of substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate in human by patch test.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- Case report of contact dermatitis proceeded by patch test.
- Specific details on test material used for the study:
- - Name of test material : sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula : C18H14N3O3S.Na
- Molecular weight: 375.383 g/mol
- Smiles notation : c1(Nc2ccccc2)ccc(\N=N\c2cc(ccc2)S(=O)(=O)[O-])cc1.[Na+]
- InChl : 1S/C18H15N3O3S.Na/c22-25(23,24)18-8-4-7-17(13-18)21-20-16-11-9-15(10-12-16)19-14-5-2-1-3-6-14;/h1-13,19H,(H,22,23,24);/q;+1/p-1/b21-20+;
- Substance type: Organic
- Physical state: Solid - Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- female
- Details on test animals and environmental conditions:
- No data
- Route:
- other: dermal
- Vehicle:
- not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- 4 days
- Adequacy of induction:
- not specified
- No. of animals per dose:
- 1 human female
- Details on study design:
- Not specified
- Challenge controls:
- Not specified
- Positive control substance(s):
- not specified
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 96
- Group:
- test chemical
- Dose level:
- not specified
- No. with + reactions:
- 3
- Clinical observations:
- lesions were observed
- Remarks on result:
- positive indication of skin sensitisation
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate was observed to show positive reactions in Human patch test for skin sensitisation.
- Executive summary:
A female patient worked in a leather (and paper) shop, selling various leather items, such as purses, pocket books, photo albums, document portfolios, wallets and writing cases. Whenever she worked in this shop, which was usually for 2 days a week, she developed dermatitis on left side of the neck. Hence the patch test was carried out for the test substance. Patch test with the scrapings of the material remained negative. However, patch testing with the leather series gave a +++ reaction to the test substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (acid yellow/metanil yellow) at 2, 3 and 4 days. On giving up working in this shop, and subsequent avoidance of contact with leather articles, her lesions healed completely. Therefore, the test substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate was considered to be a skin sensitiser and can be classified as Skin sensitiser category 1 according to CLP criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Skin sensitisation:
In different studies, sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (CAS No. 587-98-4) has been investigated for potential of skin sensitization to a greater or lesser extent. The studies are based on in vivo experiments in guinea pig and human for target and its structurally similar read across substance. The predicted data Danish QSAR database has also been compared with the experimental data of target and read across.In a case study obtained from Contact Dermatitis 31: 117–118, 1994, a female patient worked in a leather (and paper) shop, selling various leather items, such as purses, pocket books, photo albums, document portfolios, wallets and writing cases. Whenever she worked in this shop, which was usually for 2 days a week, she developed dermatitis on left side of the neck. Hence the patch test was carried out for the test substance. Patch test with the scrapings of the material remained negative. However, patch testing with the leather series gave a +++ reaction to the test substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (acid yellow/metanil yellow) at 2, 3 and 4 days. On giving up working in this shop, and subsequent avoidance of contact with leather articles, her lesions healed completely.
Supporting above study, QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization was estimated to be positive on guinea pig and human for sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate. Thus it can be concluded that the substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate has positive skin sensitization effects.
Further, the above data for target is supported by a case report of structurally similar substance 1-phenylazo-2-naphthol (CAS No. 842-07-9), from Contact Dermatitis 12: 15-17; 1985, in which a 51-year-old man had been working in dye factory for 25 years and had noticed itching and pigmentation on the extremities for the past 5 years. On examination there were erythematous lesions, lichenification and pigmentation, diffusely and symmetrically over the dorsa of the hands, feet and legs. Patch test was performed having concentration of Sudan I is 1%. They were applied on the back for 48 hours, and the test read 1h and 24 h after removal according to the ICDRG Classification. Positive reaction was observed for to 1-phenylazo-2-naphthol (Sudan I).Therefore 1-phenylazo-2-naphthol (Sudan I) was considered to be a skin sensitizer.
Thus, based on the above data of sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (CAS 587-98-4)as well as its read across and applying weight of evidence, it can be concluded that sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate may cause skin sensitisation. Thus comparing the above annotations with the criteria of CLP regulation, sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate can be considered as a skin sensitiser under category 1.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Thus, based on the above data of sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (CAS 587-98-4)as well as its read across and applying weight of evidence, it can be concluded that sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate may cause skin sensitisation. Thus comparing the above annotations with the criteria of CLP regulation, sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate can be considered as a Skin Sensitiser under category 1.
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