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EC number: 208-736-6 | CAS number: 540-10-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 March to 29 June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 0.846 µg/L
- Temp.:
- 20 °C
- pH:
- 6.3
Reference
Study results
Quantitative determination of the analyte
The results of the two experiments are summarized in the following table:
Flow rate [mL/h] |
Fraction No. |
Volume of combined fractions [mL] |
Test Item [µg/L] |
12.5 |
1 (1-2) |
20 |
< 0.846 |
2 (3-4) |
20 |
< 0.846 |
|
3 (5-6) |
20 |
< 0.846 |
|
4 (7-8) |
20 |
< 0.846 |
|
5 (9-10) |
20 |
< 0.846 |
|
6 (11-12) |
20 |
< 0.846 |
|
7 (13-14) |
20 |
< 0.846 |
|
8 (15-16) |
20 |
< 0.846 |
|
6.25 |
1 (1-2) |
20 |
< 0.846 |
2 (3-4) |
20 |
2.33 |
|
3 (5-6) |
20 |
< 0.846 |
|
4 (7-8) |
20 |
< 0.846 |
|
5 (9-10) |
20 |
< 0.846 |
|
6(11-12) |
20 |
< 0.846 |
|
7(13-14) |
20 |
< 0.846 |
|
8 (15-16) |
20 |
< 0.846 |
As described in OECD 105 a concentration plateau is reached, if at least 5 consecutive fractions do not differ by more than 30%. This is achieved for all evaluations, except the evaluation of the second run at a flow rate of 6.25 mL/h. Determination of the water solubility at both flow rates yielded values below the limit of quantification (LOQ).
The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.
Description of key information
Water solubility < 0.846 µg/L at 20 °C, pH 6.3 (OECD Guideline 105, column elution method)
Key value for chemical safety assessment
Additional information
Determination of the water solubility yielded values below the limit of quantification (LOQ = 0.846 µg/L, as determined by calibration)
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