Potassium dicyanoargentate

Endpoint summary

Description of key information

Acute toxicity studies by oral, inhalation and dermal routes of administration were waived on the basis of the positive results in the in vitro human epidermis (he-EpiDerm) conducted in accordance with OECD431 test guideline and in vitro eye irritation test (BCOP) conducted in accordance with OECD437 test guideline, or as a consequence of the low respirable fraction and large particle size determined in dustiness testing.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to GHS and EU CLP 1272/2008, potassium dicyanoargentate is classified as category 1A for skin corrosion, as an adverse effect was observed within an hour with 3 minutes of exposure to the substance.

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
In addition to the GHS and EU CLP 1272/2008 classification for skin corrosion (Category 1A), inhalation studies have also been waived based on dustiness data. Dustiness data for this substance showed that the respirable fraction (2.30 mg/g) is just 4.3% of the total inhalable fraction (52.94 mg/g) which leaves the majority (95.7%) which is not respired (sneezed or swallowed). These data reflect the particle size data (MMAD 34.9µm) when considering that respirable particles are usually under approximately 10 µm.

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to GHS and EU CLP 1272/2008 the test substance is classified as Category 1A for skin corrosion.

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

According to GHS and EU CLP 1272/2008, potassium dicyanoargentate is classified as category 1A for skin corrosion, as an adverse effect was observed within an hour with 3 minutes of exposure to the substance, and category 1 for effects on the eye, as a positive result was determined in a BCOP assay. Consequently, all acute toxicity tests by oral, inhalation and dermal routes of administration have been waived.

Justification for classification or non-classification

Following the waiver for conducting any acute in vivo tests as a consequence of the skin corrosivity and eye irritancy of the test substance, no formal classification for acute toxicity can be assigned. However, it is assumed that, due to the corrosive nature of the substance, a Category 1 result would be expected by either oral, inhalation or dermal exposures.