Registration Dossier
Registration Dossier
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EC number: 206-075-8 | CAS number: 299-28-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February - March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Name: 28723 - Ca-Gluconate
- Aggregate state at room temperature: solid
- Colour: white
- Expiry Date: March 27, 2018
- Storage conditions at test facility: at 20 °C ± 5 °C, in the dark - Key result
- Water solubility:
- 30.8 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 50 g/L
- Incubation duration:
- 24 - 72 h
- Temp.:
- 20 °C
- pH:
- 6.5 - 6.7
- Conclusions:
- The water solubility was determined to be 30.8 g/L at 20 °C.
- Executive summary:
The purpose of this study was to evaluate the solubility of the test item in water which is specified by the saturation mass concentration of the test item in water at a specified temperature. The study was performed in accordance with OECD test method no. 105 using the shake flask method. The saturation mass concentrations of the test item were determined using LC-MS/MS. The results showed no tendency to increase time-dependent; therefore the study is considered to be valid. Corresponding to the analyses the water solubility was determined to be 30.8 g/L at 20 °C.
Reference
Description of key information
The purpose of this study was to evaluate the solubility of the test item in water which is specified by the saturation mass concentration of the test item in water at a specified temperature. The study was performed in accordance with OECD test method no. 105 using the shake flask method. The saturation mass concentrations of the test item were determined using LC-MS/MS. The results showed no tendency to increase time-dependent; therefore the study is considered to be valid. Corresponding to the analyses the water solubility was determined to be 30.8 g/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 30.8 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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