Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-509-3 | CAS number: 141-91-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Toxicity:
- oral: LD50= 1270 mg/kg bw (rat);
- inhalation: Inhalation Risk Test: mortality after 3 h exposure to saturated vapor;
- dermal: LD50 > 1000 and < 2000 mg/kg bw (rat)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Internal test method, see details in "Any other information on materials and methods incl. tables"
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 266 g (mean), females: 200 g (mean)
- Fasting period before study: 16-20 h
- Diet: Herlian MRH-Haltung, ad libitum - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6.81, 10.0, 14.7, 21.5, 31.60 % - Doses:
- 681, 1000, 1470, 2150, 3160 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and daily thereafter
- Frequency of weighing: days 0, 2-4, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 270 mg/kg bw
- 95% CL:
- 1 035 - 1 551
- Mortality:
- See details in table in "Any other information on results incl. tables".
- Clinical signs:
- other: Dyspnoea, apathy, staggering, atony, tremor, spastic gait, convulsions, ruffled fur, cyanosis, exsiccosis, salivation, poor general state
- Body weight:
- other body weight observations
- Remarks:
- initially weight loss; see details in table in remarks on results
- Gross pathology:
- Heart: dilatation (right), congestion hyperemia;
Stomach: strong, diffuse redding, bloody content;
Gut: dark-diffuse redding of mucosa, diarrhoea; - Interpretation of results:
- Category 4 based on GHS criteria
Reference
Mortality:
Dose mg/kg bw |
Conc. % |
Dead animals |
3160 |
31.6 |
5/5 m, 5/5 f |
2150 |
21.5 |
5/5 m, 3/5 f |
1470 |
14.7 |
4/5 m, 4/5 f |
1000 |
10 |
1/5 m, 2/5 f |
681 |
6.81 |
0/5 m, 0/5 f |
Weight:
Dose (mg/kg bw) |
gender |
day 0 |
day 2-4 |
day 7 |
day 14 |
3160 |
m |
290 |
- |
- |
- |
3160 |
f |
210 |
- |
- |
- |
2150 |
m |
240 |
- |
- |
- |
2150 |
f |
180 |
184 |
207 |
223 |
1470 |
m |
250 |
235 |
277 |
312 |
1470 |
f |
200 |
193 |
215 |
232 |
1000 |
m |
260 |
244 |
295 |
328 |
1000 |
f |
200 |
199 |
214 |
231 |
681 |
m |
290 |
309 |
364 |
348 |
681 |
f |
210 |
224 |
269 |
242 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 270 mg/kg bw
- Quality of whole database:
- The quality of the whole database is good.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Internal test method, see details in "Any other information on materials and methods incl. tables"
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: ca. 50 cm2
REMOVAL OF TEST SUBSTANCE
- Washing (if done): water/Lutrol (1:1)
- Time after start of exposure: 24 h - Duration of exposure:
- 14 days
- Doses:
- 1000, 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Mortality:
- see details in table in remarks on results.
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- no data
- Gross pathology:
- Animals that died:
Heart: acute dilatation of the ventricle acute congestion;
Stomach: bloody ulcerations;
Liver: grey-colored lobular periphery; - Interpretation of results:
- Category 4 based on GHS criteria
Reference
Mortality:
Dose mg/kg |
Conc. % |
Animal |
1 h |
24 h |
48 h |
7 days |
14 days |
2000 |
100 |
3 m 3 f |
0/3 0/3 |
2/3 3/3 |
3/3 3/3 |
3/3 3/3 |
3/3 3/3 |
1000 |
100 |
3 m 3 f |
0/3 0/3 |
0/3 0/3 |
0/3 1/3 |
0/3 1/3 |
0/3 1/3 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 1 000 - < 2 000 mg/kg bw
- Quality of whole database:
- The quality of the whole database is good.
Additional information
Oral:
In a study which was in large parts equivalent to methods described in OECD guideline 401, the LD50 for oral acute toxicity in rats was calculated as 1270 mg/kg body weight (BASF AG, 1981; Val. 2). Doses of 681, 1000, 1470, 2150, 3160 mg/kg bw of the test substance were applied by gavage followed by a post dose observation period of 14 days. In an earlier, similar study a LD50 for oral acute toxicity of the test substance in rats was calculated as 2380 mg/kg bw (BASF AG, 1975; Val. 2). In both studies dyspnoea, apathy, staggering, atony, tremor, spastic gait, convulsions, ruffled fur, cyanosis, exsiccosis, salivation and poor general state of the animals were observed. At necropsy, dilatation and congestive hyperemia of the heart and haemorrhagic stomachs were observed.
In a further study with only limited data provided, the test substance caused likewise moderate toxicity after a single ingestion (LD50 = 2830 mg/kg bw; Smyth et al.1962; Val. 2).
Inhalation:
Data is available from an inhalation risk test (IRT) which meets generally accepted scientific principles (BASF AG, 1981; Val. 2). The inhalation of a saturated vapor-air mixture of the test substance for 3 hours caused mortality. Clinical signs were escape attempts, eyelid closure, dyspnea, loss of pain reflex, tremor, irregular gait, ruffled fur.
In a second IRT the inhalation of a saturated vapor-air-mixture of 4000 ppm of the test substance for 4 h caused no mortality (Smyth et al. 1962; Val. 2).
Dermal:
The test substance was applied by to the skin of groups of 3 rats/sex at doses of 1000 and 2000 mg/kg bw in an occlusive dressing for 24 hours (BASF AG, 1981; Val. 2). Following treatment, rats were observed daily and a gross necropsy examination was performed at the time of scheduled euthanasia (day 14). All animals in the 2000 mg/kg bw dose group died within 48 h and one female died in the 1000 mg/kg bw dose group. As a result an acute dermal LD50: > 1000 and < 2000 mg/kg bw was determined. Main clinical signs observed were dyspnoea, apathy, staggering, tremor, spastic gait, ruffled fur, diarrhea, cyanosis, exsiccosis, eyelid closure and poor general state. Additionally, severe cutaneous reactions (necrosis associated with edema) were noted. At necropsy, dilatation and congestive hyperemia of the heart, haemorrhagic stomachs and grey-colored lobular periphery of the liver were observed.
In a further study with only limited data provided, an acute dermal LD50 of the test substance for rabbits of 662 mg/kg bw (710 ml/kg bw) was calculated (Smyth et al.1962; Val. 2).
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. Based on the determined LD50 values in the acute oral and dermal toxicity studies, the substance is classified for acute oral and dermal toxicity Cat. 4 (H302 and H312) under Regulation (EC) No. 1272/2008, as amended for the seventeenth time in Regulation (EC) No. 2021/849.
The available studies on acute toxicity by inhalation are not suitable to assess this route of exposure, but the results suggest a LC 50 value greater than 20 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.