Registration Dossier
Registration Dossier
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EC number: 205-305-4 | CAS number: 137-66-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 26 May 2015 and 25 September 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 6-O-palmitoylascorbic acid
- EC Number:
- 205-305-4
- EC Name:
- 6-O-palmitoylascorbic acid
- Cas Number:
- 137-66-6
- Molecular formula:
- C22H38O7
- IUPAC Name:
- 6-O-palmitoylascorbic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 30 °C
- pH:
- ca. 1.9
Any other information on results incl. tables
Preliminary Estimate
Estimated log10Pow: 6.00
Main Test
Partition coefficient of the sample
The retention times, capacity factor and log Powvalue determined for the sample are shown in the following table:
Injection |
Retention Time (min) |
Capacity Factor (k') |
Log10k' |
Log10Pow |
1 |
40.975 |
24.4 |
1.39 |
>6.5 |
2 |
40.975 |
24.4 |
1.39 |
>6.5 |
Overall log10Pow: >6.5
Partition coefficient: >3.16 x 106
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item as logPow has been determined to be greater than greater than 6.5.
- Executive summary:
The partition coefficient of the test item has been determined to be greater than 3.16 x 106,
log10Powgreater than 6.5.
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