Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-541-5 | CAS number: 122-40-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Toxicity to reproduction via oral route
The no observed adverse effect level (NOAEL) for maternal toxicity was considered to be 510.97 mg/kg bw/day.When rats were treated with 2-benzylideneheptanal (122-40-7) orally.
Link to relevant study records
- Endpoint:
- toxicity to reproduction
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Prediction is done using OECD QSAR toolbox version 3.4 and the supporting QMRF report has been attached.
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- Prediction is done using OECD QSAR Toolbox version 3.4
- GLP compliance:
- not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-benzylideneheptanal
- Molecular formula: C14H18O
- Molecular weight : 202.2952 g/mole
- Substance type: Organic
- Physical state:Liquid - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Premating exposure period: 14 d
Total exposure period: males 47 d, females 46 d. - Frequency of treatment:
- Daily
- Dose / conc.:
- 510.97 mg/kg bw/day
- No. of animals per sex per dose:
- 25
- Control animals:
- not specified
- Parental animals: Observations and examinations:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: Yes
BODY WEIGHT: Yes
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): No data
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data
- Postmortem examinations (parental animals):
- GROSS NECROPSY: Yes
HISTOPATHOLOGY / ORGAN WEIGHTS: Yes - Clinical signs:
- no effects observed
- Description (incidence and severity):
- No test substance related effects observed
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- No test substance related effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No test substance related effects observed
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- no effects observed
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- no effects observed
- Description (incidence and severity):
- No test substance related effects observed
- Dose descriptor:
- NOAEL
- Effect level:
- 510.97 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- clinical signs
- body weight and weight gain
- histopathology: non-neoplastic
- reproductive performance
- other: No effects observed.
- Remarks on result:
- other: No effect was observed
- Critical effects observed:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Relation to other toxic effects:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Conclusions:
- The no observed adverse effect level (NOAEL) for maternal toxicity was considered to be 510.97 mg/kg bw/day.When rats were treated with 2-benzylideneheptanal (122-40-7) orally.
- Executive summary:
The reproductive toxicity study was predicted using OECD QSAR toolbox version 3.4 (2017); to evaluate the toxic effects of administration of 2-benzylidenehepta nal (CAS No. 122-40-7) in rat by the oral route. No effects observed on clinical signs, body weight, gross pathology and histopathology. Hence the no observed adverse effect level (NOAEL) for maternal toxicity was considered to be 510.97 mg/kg bw/day.When rats were treated with 2-benzylideneheptanal (122-40-7) orally.
Reference
The
prediction was based on dataset comprised from the following
descriptors: NOAEL
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
or "b" or "c" or "d" or "e" )
or "f" or "g" )
and "h" )
and ("i"
and (
not "j")
)
)
and ("k"
and "l" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aldehydes (Acute toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Nucleophilic
addition to alpha, beta-unsaturated carbonyl compounds AND AN2 >>
Nucleophilic addition to alpha, beta-unsaturated carbonyl compounds >>
Alpha, Beta-Unsaturated Aldehydes AND AN2 >> Schiff base formation AND
AN2 >> Schiff base formation >> Alpha, Beta-Unsaturated Aldehydes by DNA
binding by OASIS v.1.4
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Low reactive OR Low reactive >>
alpha-alkyl cinnamaldehyde derivatives by DPRA Cysteine peptide
depletion ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael addition
to activated double bonds OR AN2 >> Michael addition to activated double
bonds >> alpha,beta-Unsaturated Carbonyls and Related Compounds OR
Michael addition OR Michael addition >> Michael addition on
alpha,beta-Unsaturated carbonyl compounds OR Michael addition >> Michael
addition on alpha,beta-Unsaturated carbonyl compounds >>
alpha,beta-Aldehydes OR Schiff base formation OR Schiff base formation
>> Schiff base formation with carbonyl compounds OR Schiff base
formation >> Schiff base formation with carbonyl compounds >> Aldehydes
by Protein binding by OASIS v1.4 ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Michael addition OR Michael
addition >> Polarised Alkenes OR Michael addition >> Polarised Alkenes
>> Polarised alkene - aldehydes OR Schiff Base Formers OR Schiff Base
Formers >> Direct Acting Schiff Base Formers OR Schiff Base Formers >>
Direct Acting Schiff Base Formers >> Mono-carbonyls by Protein binding
by OECD ONLY
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Aldehydes by Acute aquatic
toxicity MOA by OASIS
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Vinyl/Allyl Aldehydes by Aquatic
toxicity classification by ECOSAR
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Aldehydes by Acute aquatic
toxicity MOA by OASIS ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 16
- Oxygen O by Chemical elements
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Group 1 - Alkali Earth
Li,Na,K,Rb,Cs,Fr OR Group 13 - Metals Al,Ga,In,Tl by Chemical elements
Domain
logical expression index: "k"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -1.67
Domain
logical expression index: "l"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.37
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 510.97 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The data is Klimicsh 2 and from OECD QSAR toolbox version 3.4 (2017).
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Toxicity to reproduction via oral route
Various studies including predicted results from the validated model and experimental study has been investigated for reproductive toxicity to a greater or lesser extent for the test chemical 2-benzylideneheptanal (CAS No. 122-40-7) along with its structurally similar read across substance α-hexylcinnamaldehyde (CAS No. 101 -86 -0) and 2-(4-tert-butylbenzyl) propionaldehyde) (CAS No. 80-54-6).The predicted data for target chemical 2-benzylidenehepta nal (CAS No. 122-40-7) has been compared with experimental study for a read across substance. The studies are summarized as below:
The reproductive toxicity study was predicted using OECD QSAR toolbox version 3.4 (2017); to evaluate the toxic effects of administration of 2-benzylidenehepta nal (CAS No. 122-40-7) in rat by the oral route. No effects observed on clinical signs, body weight, gross pathology and histopathology. Hence the no observed adverse effect level (NOAEL) for maternal toxicity was considered to be 510.97 mg/kg bw/day.When rats were treated with 2-benzylideneheptanal (122-40-7) orally.
This is further supported by the one generation study published in a report of (Human Health Tier II Assessment For Amyl and hexyl cinnamaldehy de (2017))on structurally similar read across substance α-hexylcinnamaldehyde (CAS No.-101-86-0).In a one generation study conducted similarly to OECD TG 421, Crj: CD (SD) rats (eight animals/sex/dose) were fed α-hexylcinnamaldehyde (CAS No.-101-86-0) in corn oil at 12.5, 25, 50 or 1000 mg/kg bw. The males received the treatment for 14 days before cohabitation,through mating for a maximum of seven days and were euthanised on the day 47 of treatment. Female rats were treated two weeks before cohabitation, through mating and were euthanised on day 45 of treatment. The first group of offspring (FI) generation pups were euthanised on fifth day of lactation. No treatment related clinical observations or gross lesions were seen in the parent (P) generation of either sex. Body weights and feed consumption were unaffected in male rats. In treated P generation female rats, the body weights or body weight gains and the feed consumption were not affected by the treatment during the pre cohabitation and the gestation periods. A significant decrease in maternal body weight in the 1000 mg/kg bw/day dose group was reported during the lactation period and was considered as the maximum tolerated dose (MTD). No treatment related effect was seen on oestrous cycling, mating and fertility at any tested dose. No treatment related clinical or necropsy effects were seen in the F1 generation pups and no developmental effects were observed. Hence The NOAEL for maternal and developmental toxicity was considered to be >=1000 mg/kg bw/day. When rats were treated with α-hexylcinnamaldehyde (CAS No.-101-86-0) orally.
The above study is supported by the experimental study by A.M. Api et al. (Food and Chemical Toxicology Volume 82, Supplement, August 2015, Pages S20-S28), on structurally similar read across substance α-hexylcinnamaldehyde (CAS No.-101-86-0). The study was designed to investigate the reproductive toxicity effects of α-hexylcinnamaldehyde (CAS No.- 101-86-0) in rats by the oral route. No effects were observed on mating, fertility, reproductive organ weights, reproductive organ microscopic examination,delivery parameters, pup body weights, and pup clinical and necropsy observations. There were non-significant decreases in maternal body weight gain and feed consumption during lactation. hence the NOAEL for reproductive and developmental toxicity was considered to be 100 mg/kg/day, the highest dosage tested.When rats were treated with α-hexylcinnamaldehyde (CAS No.- 101-86-0) orally
Moreover, in the study published in a U.S. Environmental Protection Agency Risk-Based Prioritization Document (Initial Risk-Based Prioritization of High Production Volume (HPV) Chemicals Cinnamyl Derivatives Category), on structurally similar read across substance p-t-Butyl-alpha-methylhydrocinnamaldehyde (2-(4-tert-butylbenzyl) propionaldehyde) (CAS No.80-54-6).The study was designed to investigate the reproductive toxicity effects of p-t-Butyl-alpha-methylhydrocinnamaldehyde (2-(4-tert-butylbenzyl) propionaldehyde) (CAS No.80-54-6) in dogs by the oral route. Beagle dogs (6/sex/dose) were administered p-t-butyl-alpha-methylhydrocinnamaldehyde orally via gelatin capsules at 4.4, 22.3 and 44.6 mg/kg-bw/day for 91 days. No adverse effects on body weight, behavior, haematological, clinical parameters or histopathology were observed at any dose. Histological evaluation was performed on the male and female reproductive organs from each dose group and the control group. In the high dose males, the presence of spermatoceles and testicular atrophy were seen. No treatment-related effects on the female reproductive system were observed. Hence NOAEL was considered to be for male dogs = 22.3 mg/kg bw/day and female dogs = 44.6 mg/kg bw/day.When Beagle dogs were treated with p-t-Butyl-alpha-methylhydrocinnamaldehyde (2-(4-tert-butylbenzyl) propionaldehyde) (CAS No.80-54-6) orally.
So, based on the above mentioned studies for target substance 2-benzylideneheptanal (CAS No. 122-40-7) and to its read across substance, it was considered that no adverse effects on sexual function and fertility was observed. Therefore, according to CLP criteria, the substance 2-benzylidene heptanal (CAS No. 122-40-7) cannot be classified as reproductive toxicant.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Thus, comparing this value with the criteria of CLP regulation2-benzylideneheptanal (CAS No. 122-40-7) can be "Not classified" for reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.