Registration Dossier
Registration Dossier
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EC number: 204-407-6 | CAS number: 120-55-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
No dermal reactions were observed following a single semi-occlusive application of DEGDB to intact rabbit skin for four hours.
Neat test material (0.1 ml) was instilled into one eye of six healthy adult rabbits, and the effects observed for three days (72h).
Transient hyperaemia of blood vessels only was observed in all animals. These reactions had resolved in all instances by one or two days after instillation. No corneal damage or iridial inflammation was observed. Similar findings were seen in a much earlier (non-GLP) study and the same conclusion was made.
As a single instillation of DEGDB into the rabbit eye did not elicit a positive response according to the established test criteria, it is therefore considered as non-irritant.
Justification for classification or non-classification
According to the criteria laid down in Council Directive 67/548/EEC (and subsequent adaptations), DEGDB is considered not irritant to the skin or the eye and is not classified.
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