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EC number: 204-004-5 | CAS number: 112-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No death occurred at concentrations up to 3850 mg/kg. The LD50 value is > 5000 mg/kg. Therefore the test substance is considered to be low toxicity after oral administration. No death occurred when animals are exposed to a saturated atmosphere of stearoyl chloride for 8 h. The inhalation of a saturated atmosphere represents no acute hazard.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Adult laboratory rats were purchased from a breeder. Usually the source and strain of the animals were not documented. Several groups of 5 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in a suitable vehicle. The concentrations of these preparations were usually adjusted to achieve comparable volumes (e.g. 10 ml) per kg body weight.
Group-wise documentation of clinical signs was performed over the 14- day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. More details e.g. on substance preparation, or dose and time dependence of symptoms, can be inferred from the German hand written raw data.
On the basis of the observed lethality, the LD50 value was determined by probit analysis. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100%, 76,6%, 43 %, 20 %, 9,3 %
- Justification for choice of vehicle: low toxicity, stability and soulubility of the test subsance
MAXIMUM DOSE VOLUME APPLIED:
1,56 ml
- Doses:
- 464, 1000, 2150, 3830, 5000, 6810, 8250 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Observations: <15 min; 15 min 30 min, 1 h, 2 h, 4 h, 5 h post administration on the day of administration , once daily thereafter except on weekends and holidays
Weighing: prior to administration, on day 7 and at termination of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Probit analysis
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 783 mg/kg bw
- 95% CL:
- >= 5 047 - <= 6 570
- Mortality:
- no mortality occorred in doses up to 3830 mg/kg (details see table below)
- Clinical signs:
- other: Apathy, ataxia, tremor, irregular respiration, abdominal posture, poor general condition (details see table below)
- Gross pathology:
- 5000, 6810, 8250 mg/kg: stomach ulcer, bloody stomach, necrotic stomach mucosa, diarrhea
464, 1000, 2150, 3830 mg/kg: nothing abnormal detected - Executive summary:
The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. only
mean bodyweight reported). Groups of 5 male and 5 female rats were gavaged at dose levels of 464, 1000, 2150, 3830, 5000, 6810 and 8250 g/kg bw. The post-exposure observation period was 14 days. Clinical signs like tremor, apathy, unsteady respiration were observed 1 h until day 1 after administration. No death occurred at concentrations up to 3850 mg/kg. The LD50 value is 5783 mg/kg. Therefore, the testsubstance is considerd to be relatively harmless after oral administration.
Conclusion
No death occurred at concentrations up to 3850 mg/kg. The LD50 value is > 5000 mg/kg. Therefore the test substance is considerd to be relatively harmless after oral administration.
Reference
Dose [mg/kg] |
Mortality |
Clinical observation
|
Mean body weight [g] |
8250 |
5/5 male 5/5 female |
Apathy, ataxia, tremor, irregular respiration, abdominal posture, poor general condition |
Beginning: 180 g (male) ; 160 g (female) Day 7: - Day 14: - |
6810 |
3/5 male 3/5 female |
Apathy, ataxia, tremor, irregular respiration, poor general condition |
Beginning: 190 g (male) ; 160 g (female) Day 7: 210 g (male) ; 186 g (female) Day 14: 238 g (male) ; 203 g (female) |
5000 |
1/5 male 2/5 female |
Apathy, ataxia, irregular respiration, poor general condition |
Beginning: 230 g (male) ; 180 g (female) Day 7: 254 g (male) ; 205 g (female) Day 14: 260 g (male) ; 230 g (female) |
3830 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 190 g (male) ; 160 g (female) Day 7: 255 g (male) ; 188 g (female) Day 14: 295 g (male) ; 199 g (female) |
2150 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 200 g (male) ; 170 g (female) Day 7: 269 g (male) ; 211 g (female) Day 14: 301 g (male) ; 226 g (female) |
1000 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 200 g (male) ; 170 g (female) Day 7: 247 g (male) ; 209 g (female) Day 14: 298 g (male) ; 219 g (female) |
464 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 210 g (male) ; 170 g (female) Day 7: 275 g (male) ; 208 g (female) Day 14: 300 g (male) ; 219 g (female) |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 783 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days; low number of rats)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- Annex of the Guideline
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 534 g (group 1, mean male), 440 g (group 1, mean female), 490 g (group 2; mean male), 485 g (group 2; mean female) - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Rats exposed for 8 h to a vapour saturated atmosphere at 20 °C. Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- vapour saturated atmosphere at 20 °C (vapor pressure < 1mbar at 20 °C)
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: weighing at beginning and at temination of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- male/female
- Dose descriptor:
- LC0
- Exp. duration:
- 8 h
- Remarks on result:
- other: saturated vapor
- Mortality:
- no mortality occurred
- Clinical signs:
- other: attempts to escape bloody discharge from eyes and nose
- Body weight:
- Mean body weight
group 1 male: 584 g (beginning), 679 g (termination)
group 1 female: 440 g (beginning), 534 g (termination)
group 2 male: 490 g (beginning), 607 g (termination)
group 2 female: 485 g (beginning), 594 g (termination) - Gross pathology:
- nothing abnormal detected
- Executive summary:
Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981).
6 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder. No death occurred when animals are exposed to a saturated atmosphere of stearoyl chloride for 8 h. The inhalation of a saturated atmosphere represents no acute hazard.
Conclusion
No death occurred when animals are exposed to a saturated atmosphere of stearoyl chloride for 8 h. The inhalation of a saturated atmosphere represents no acute hazard.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Groups of 5 male and 5 female rats were gavaged at dose levels of 464, 1000, 2150, 3830, 5000, 6810 and 8250 g/kg bw. The post exposure observation period was 14 days. Clinical signs like tremor apathy unsteady respiration were observed 1 h until day 1 after administration. No death occurred at concentrations up to 3850 mg/kg. The LD50 value is 5783 mg/kg. Therefore the test substance is considered to be low toxicity after oral administration. The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. only mean bodyweight reported).
6 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder. Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981). No death occurred when animals are exposed to a saturated atmosphere of stearoyl chloride for 8 h. The inhalation of a saturated atmosphere represents no acute hazard.
Justification for classification or non-classification
No classification suggested for acute toxicity as criteria of regulation 1272/2008/EC are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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