Tridecan-1-ol

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database

Qualifier:

according to guideline

Guideline:

other: As mention below

Principles of method if other than guideline:

Study was assess to evaluate the nature and effect of test chemical on the growth of algae for the exposure period of 72 hrs.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Green algae

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Reference substance (positive control):

not specified

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

0.012 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: No data available

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

0.003 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: Other details not known

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

0.09 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Biomass and area under the growth curve

Remarks on result:

other: Other details not known

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

0.017 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Biomass and area under the growth curve

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

Based on the growth rate inhibition of green algae due to the exposure of tes chemical and NOEC was 0.012 mg/l and 0.0029 mg/l. But on the basis of Biomass and area under the growth curve, the EC50 and NOEC was determine to be 0.09 mg/l and 0.017 mg/l.

Executive summary:

Study was assess to evaluate the nature and effect of test chemical on the growth of green algae for the exposure period of 72 hrs. Study was conducted under the static system. After the exposure effect was determine. Based on the growth rate inhibition of green algae due to the exposure of test chemical , the EC50 and NOEC was 0.012 mg/l and 0.0029 mg/l. But on the basis of Biomass and area under the growth curve, the EC50 and NOEC was determine to be 0.09 mg/l and 0.017 mg/l. Based on the EC50, test chemical was concluded as toxic and can be consider to be classified as aquatic acute 1 as per the CLP classification criteria.

Description of key information

Study was assess to evaluate the nature and effect of test chemical on the growth of green algae for the exposure period of 72 hrs. Study was conducted under the static system. After the exposure effect was determine. Based on the growth rate inhibition of green algae due to the exposure of test chemical , the EC50 and NOEC was 0.012 mg/l and 0.0029 mg/l. But on the basis of Biomass and area under the growth curve, the EC50 and NOEC was determine to be 0.09 mg/l and 0.017 mg/l. Based on the EC50, test chemical was concluded as toxic and can be consider to be classified as aquatic acute 1 as per the CLP classification criteria.

Key value for chemical safety assessment

EC50 for freshwater algae:

0.012 mg/L

EC10 or NOEC for freshwater algae:

0.003 mg/L

Additional information

Based on the various experimental data for the target chemical study have been reviewed to determine the toxic nature on the growth of aquatic algae and cyanobacteria. The studies are as mentioned below:

 

In the first key study for the target chemical was described in authorative database,

Study was assess to evaluate the nature and effect of test chemical on the growth of green algae for the exposure period of 72 hrs. Study was conducted under the static system. After the exposure effect was determine. Based on the growth rate inhibition of green algae due to the exposure of test chemical , the EC50 and NOEC was 0.012 mg/l and 0.0029 mg/l. But on the basis of Biomass and area under the growth curve, the EC50 and NOEC was determine to be 0.09 mg/l and 0.017 mg/l. Based on the EC50, test chemical was concluded as toxic and can be consider to be classified as aquatic acute 1 as per the CLP classification criteria.

 

Similarly in the second supporting study for the target chemical from secondry source says that the chemical was toxic. Study was assess to evaluate the nature and effect of test chemical on the growth of algae for the exposure period of 72 hrs. After the exposure of chemical for 72 hrs, the EC50 was determine to be 0.1-1 mg/l. Based on the EC50, test chemical was concluded as toxic and can be consider to be classified as aquatic acute 1 as per the CLP classification criteria.

 

The fourth study consider for the test chemical from authorative database. Study was assess to evaluate the nature and effect of test chemical on the growth of green algae for the exposure period of 72 hrs. Study was conducted under the static system. After the exposure effect was determine. Based on the growth rate inhibition of green algae due to the exposure of test chemical , the EC50 and NOEC was 0.56 mg/l and 0.028 mg/l. But on the basis of Biomass and area under the growth curve, the EC50 and NOEC was determine to be 0.72 mg/l and 0.09 mg/l. Based on the EC50, test chemical was concluded as toxic and can be consider to be classified as aquatic acute 1 as per the CLP classification criteria.

 

Based on the experimental data for the test chemical it can be concluded that the substance is considered to be toxic to aquatic algae and cyanobacteria and classified as aquatic acute 1 category as per the CLP classification criteria.