Registration Dossier
Registration Dossier
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EC number: 203-475-4 | CAS number: 107-25-5
Carcinogenicity
Administrative data
Description of key information
No carcinogenicity study available.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Classification for carcinogenicity is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
Methyl vinyl ether (MVE), ethyl vinyl ether (EVE, CAS 109-92-2), isobutyl vinyl ether (IBVE, CAS 109-53-5) and hydroxybutylvinylether (HBVE, CAS 17832 -28 -9) were not mutagenic in the Ames test or in mammalian cell systems both in the absence and presence of metabolic activation. EVE, IBVE and HBVE did not induce chromosomal aberrations in Chinese Hamster cells. In vivo, MVE did not induce micronuclei in bone marrow of mice. The members of this category appear to have no potential to induce gene mutations or chromosomal aberrations.
MVE is practically exclusively used as intermediate in the manufacture of vinyl ether polymers and co-polymers. At room temperature, MVE is an extremely flammable gas and may generate explosive atmospheres.
Worker exposure to MVE is controlled by the use of closed systems, industrial hygiene controls, and personal protective equipment. Potentially existing residual MVE is expected to evaporate during the process of heat-treatment (OECD SIDS 2006). Therefore, no exposure of the general population is expected. The conduct of carcinogenicity testing is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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