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EC number: 202-131-0 | CAS number: 92-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed study performed before OECD, no GLP stated
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- Principles of method if other than guideline:
- 10 daphnia magna neonates (< 24 hours old) were exposed to two concentrations (85 mg/L, 8.5 mg/L) of the test substance in 96 hour static aquatic effect test in order to assess the environmental impact of the test substance. The objectives of this test were (a) to determine if acute exposures to concentrations of the test substance would aaffect daphnids adversely and (b) if appropriate, provide estimates of the 24-, 48-, 72- and 96 hour EC50 values and the highest concentration causing no significant immobility (< 10%) within the period of the test. The daphnids were observed for signs of stress, as well as immobility during the period of exposure to the test substance.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2'-methoxyacetoacetanilide
- EC Number:
- 202-131-0
- EC Name:
- 2'-methoxyacetoacetanilide
- Cas Number:
- 92-15-9
- Molecular formula:
- C11H13NO3
- IUPAC Name:
- N-(2-methoxyphenyl)-3-oxobutanamide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 23 liters of conditoned water were passed through 2.3 g of test substance at 100 mL/minute for 96 hours. The concentration was determined to 85 mg/L (UV).. This was the highest achievable concentration
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Adult daphnia magna were reared within 100 L culturing tanks. The gravid daphnids used to produce the test animals for the study were obtained from rearing tanks. Prior to the study appr. 100 gravid daphnids were transferred by net into two glass bowls containing diluent water and food. After appr. 18 hour in these bowls, all adult daphnids were removed by usng nets and pipettes. A total of 10 daphnid neonates were transferred from the culturing bowls into stainless steel mesh baskets suspended in the exposure solution vessels.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- no data
- Test temperature:
- 18 - 19 °C
- pH:
- 7.5 - 8.3
- Dissolved oxygen:
- 7.4 - 9.1 mg/L
- Salinity:
- no data
- Nominal and measured concentrations:
- 8.5 mg/L and 85 mg/L
- Details on test conditions:
- The acute test was püerformed by placing the test organisms in stainless steel mesh baskets suspended in glass aquaria containing 20 L of exposure solution. each basket was suspended from a small motor that slowly raised and lowered the position of the basket within the test solution. The light/dark cycle of the photoperiod during the test was 16 hours on / 8 hours off with a 20 minute transition period
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 24-, 48-, 72- and 96 hours EC50 value for daphnia magna were eatimated to be < 85 mg/L. The highest tested concentration causing no significant immobility (< 10%) within the period of the test was determined to be 85 mg/L..
The 96 hour EC50 value indicates that, based on this test, the test substance would not be classified according the EU labeling directive and would correspond to a "low concern level" according to the U.S. EPA's assessment criteria.
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