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EC number: 201-381-8 | CAS number: 81-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-12-01 - 1988-12-29 (experimental phase)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study conducted before 2008
Test material
- Reference substance name:
- 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
- EC Number:
- 201-381-8
- EC Name:
- 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
- Cas Number:
- 81-85-6
- Molecular formula:
- C17H10BrNO2
- IUPAC Name:
- 6-bromo-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): secondary effluent of a domestic sewage treatment plant (Wupper area water authority, STP Odenthal)
- Pretreatment: separation of coarse particles by filtration; aeration of filtrate
- Concentration of sludge: 5 ml/L (effluent concentration in reaction mixture) - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 51.2 mg/L
- Based on:
- test mat.
- Initial conc.:
- 1.56 other: mg O2/mg
- Based on:
- COD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium
- Test temperature: 20 ± 1 °C
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
BOD5 / COD results
BOD5 / COD
- Parameter:
- COD
- Value:
- 1.56 other: mg O2/mg
- Results with reference substance:
- 88% degradation after 28 days has been determined with the reference substance aniline.
Theoretical Oxygen Demand (ThOD): 2409 mg/g
Any other information on results incl. tables
Degradation of test item
5d | 15d | 28d | |
BOD (mg/L) | 0.50 | 0.45 | 0.50 |
% degradation | 1 | 1 | 1 |
Degradation of reference substance
Test concentration: 1.2 mg/L
5d | 15d | 28d | |
BOD (mg/L) | 1.95 | 2.35 | 2.55 |
%degradation | 67 | 81 | 88 |
Oxygen measurement
Dissolved oxygen of mineral medium:
(mg O2/L after x days)
bottle-no. | 0 days |
1 | 9.3 |
2 | 9.3 |
mean | 9.3 |
Dissolved oxygen of blank inoculum:
(mg O2/L after x days)
bottle-no. | 0 days | bottle-no. | 5 days | bottle-no. | 15 days | bottle-no. | 28 days |
3 | 8.80 | 5 | 8.80 | 7 | 8.70 | 9 | 8.70 |
4 | 8.80 | 6 | 8.80 | 8 | 8.70 | 10 | 8.70 |
mean | 8.80 | 8.80 | 8.70 | 8.70 |
Dissolved oxygen of test item:
(mg O2/L after x days)
bottle-no. | 0 days | bottle-no. | 5 days | bottle-no. | 15 days | bottle-no. | 28 days |
11 | 8.90 | 13 | 8.80 | 15 | 8.70 | 17 | 8.70 |
12 | 8.80 | 14 | 8.80 | 16 | 8.80 | 18 | 8.70 |
mean | 8.85 | 8.80 | 8.75 | 8.70 |
Dissolved oxygen of reference substance:
(mg O2/L after x days)
bottle-no. | 0 days | bottle-no. | 5 days | bottle-no. | 15 days | bottle-no. | 28 days |
19 | 8.80 | 21 | 7.40 | 23 | 6.80 | 25 | 6.70 |
20 | 8.80 | 22 | 7.30 | 24 | 6.90 | 26 | 6.60 |
mean | 8.80 | 7.35 | 6.85 | 6.65 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The study was conducted according to OECD 301 F on the registered substance itself. The method is to be considered scientifically reasonable and suitable for the test item with some deficiencies in documentation, but the available information allows the conclusion that the test was properly conducted. Hence, the results can be considered as reliable to assess ready biodegradability of the test item. A degradation of 1 % was determined, hence, the test item needs to be classified as not readily biodegradable.
- Executive summary:
This report is based on a study report “Biodegradability of Pyridon, rein, trocken" (1988), the corresponding raw data and additional information from the executing laboratory “Institut für Umweltanalyse”, Dr. Kanne (Bayer AG Leverkusen – Germany). Recent regulatory requirements necessitate this re-evaluation.
The study was conducted in accordance EU method C.4-E. This test method is in all essential parts identical with OECD 301D.
A solution of the test item in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period, degradation was followed by BOD determinations. The reference compound aniline showed 81 % degradation after 15 days.
Result:
1 % degradation after 5 days
1 % degradation after 15 days
1 % degradation after 28 days
Therefore the test item is considered to be “not readily biodegradable“.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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