Registration Dossier
Registration Dossier
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EC number: 200-896-5 | CAS number: 75-73-0
Endpoint summary
Administrative data
Description of key information
The three analogues used for the read-across (trifluoromethane, pentafluoroethane and perfluoroethane) had low repeated-dose inhalation toxicity and presented no adverse effect up to 10 000 ppm (for trifluoromethane) to 50 000 ppm (for pentafluoromethane and perfluoroethane). As the read-across with these analogues is considered as approriate, the repeated-dose toxicity of carbon tetrafluoride is expected to be similar to these analogue’s values.
Moreover, according to Annex VII (section 8.6.1 of the Column 2) of REACH regulation, the repeated-dose oral toxicity and repeated-dose dermal toxicity studies does not need to be conducted because the substance is a gas. Consequently, during the use of the substance, inhalation is likely. Furthermore, the low Log Kow coefficient (<3) suggest a low potential for dermal absorption.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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