Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Tetralead trioxide sulphate
  • IUPAC name: tetrakis(lambda2-lead(2+)) trioxidandiide sulfate
  • Other names
EC / List no.:
235-380-9
CAS no.:
12202-17-4
Index number:
Molecular formula:
O7Pb4S
SMILES:
[O--].[O--].[O--].[Pb++].[Pb++].[Pb++].[Pb++].[O-]S([O-])(=O)=O
InChI:
InChI=1S/H2O4S.3O.4Pb/c1-5(2,3)4;;;;;;;/h(H2,1,2,3,4);;;;;;;/q;3*-2;4*+2/p-2
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
5
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may damage fertility or the unborn child, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, is harmful if inhaled, is suspected of causing cancer and may cause harm to breast-fed children.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may cause damage to organs through prolonged or repeated exposure.

Breakdown of all 64 C&L notifications submitted to ECHA

Repr. 1A H360
Aquatic Chronic 1 H410
Acute Tox. 4 H302
Acute Tox. 4 H332
Aquatic Acute 1 H400
STOT RE 1 H372
Carc. 2 H351
Lact. H362
STOT RE 2 H373
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 43 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
This substance is subject to the Prior Informed Consent regulation and to export notification procedure from 03-Dec-2015
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens), production of mixtures or articles by tabletting, compression, extrusion or pelletisation, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), open transfer and processing with minerals/metals at elevated temperature and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials, in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance can be found in complex articles, with no release intended: electrical batteries and accumulators. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones) and metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: polymers.

This substance is used for the manufacture of: electrical, electronic and optical equipment, machinery and vehicles and plastic products.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: polymers and coating products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, mixing in open batch processes, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens), production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and manufacturing of the substance.

This substance is used in the following products: polymers and coating products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products, machinery and vehicles, electrical, electronic and optical equipment, chemicals and metals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, the low energy manipulation of substances bound in materials or articles, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens) and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, of substances in closed systems with minimal release, manufacturing of the substance, formulation of mixtures and formulation in materials.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, the low energy manipulation of substances bound in materials or articles, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens), closed processes with no likelihood of exposure, transfer of substance into small containers and handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials and as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • "S.I.A.P." Sp. z o.o., Pszczyńska 206 44-100 Gliwice Poland
  • Accumulatorenwerke Hoppecke Carl Zoellner & Sohn GmbH, Bontkirchenerstr. 1 59929 Brilon Germany
  • Akkumulatorenfabrik MOLL GmbH + Co. KG, Angerstraße 50 96231 Bad Staffelstein Bavaria Germany
  • ASUA PRODUCTS, S.A., Ctra. Sangróniz, 20 E-48150 Sondica Spain
  • BAE Batterien GmbH, Wilhelminenhofstraße 69/70 12459 Berlin Germany
  • Banner GmbH, Banner Straße 1 4021 Linz Austria
  • Centurion Exploitatie BV, Montageweg 1 6045JA ROERMOND Netherlands
  • Chemson Ltd, Northumberland Dock Road NE28 OPB Wallsend, Tyne&Wear United Kingdom
  • Chemson Polymer-Additive AG, Industriestrasse 19 9601 Arnoldstein Carinthia Austria
  • Clarios Zwickau GmbH & Co. KG, Reichenbacher Str. 89 08056 Zwickau Germany
  • EnerSys AD, Industrial zone 7700 Targovishte Bulgaria
  • EnerSys Newport, Stephenson Street Newport, Gwent NP19 4XJ Newport South Wales United Kingdom
  • ENERSYS SARL, Alexander Fleming 62033 ARRAS France
  • Enersys Sp. z o.o., Leszczynska 73 43-300 Bielsko-Biala Poland
  • Exide Technologies GmbH, Thiergarten 63654 Büdingen Germany
  • EXIDE Technologies LdA, Av Dr Carlos Leal 2600-719 Castanheira do Ribatejo Portugal
  • EXIDE TECHNOLOGIES S.A., Gdynska 31/33 61-016 Poznan Poland
  • EXIDE Technologies S.A.S., 5, allée des pierres mayettes 92636 Gennevilliers France
  • EXIDE Technologies Srl, Via Dante Alighieri, 106 24058 Romano di Lombardia Bg Italy
  • Exide Technologies, S.L., Ctra. Nacional II km 41,8 19.200 Azuqueca de Henares Guadalajara Spain
  • FIAMM Energy Technology S.p.A., Viale Europa, 75 36075 Montecchio Maggiore Italy
  • FIB SRL, VIA MONTI 13 63825 MONTERUBBIANO (FM) ITALY Italy
  • Flaurea Chemicals SA, Quai des usines 12 7800 Ath Hainaut Belgium
  • FXM Batterie Manufaktur GmbH, Am Gries 29 84424 Isen Germany
  • GS Yuasa Battery Manufacturing UK Ltd, Unit 22 Rassau Industrial Estate NP23 5SD Ebbw Vale Gwent United Kingdom
  • Hawker GmbH Germany, Dieckstr. 42 58089 Hagen Germany
  • IBF s.p.a., Località macchia 71037 Monte Sant'Angelo FG Italy
  • Jenox Akumulatory Sp. z o.o., Notecka 64-800 Chodzież Poland
  • Johnson Controls Autobaterias S.A., C/Hermanos Pinzon 4 28036 Madrid Spain
  • Johnson Controls AUTOBATERIE spol. S.r.o., Dubicka 958 47090 Ceska Lipa Czech Republic
  • Johnson Controls Autobatterie GmbH & Co. KGaA, Am Leineufer 51 30419 Hannover Germany
  • LOXA Sp. z o.o., Myszkowska 61 42-310 Żarki Poland
  • Midac Spa, Via A. Volta, 2 37038 Soave Italy
  • PENOX GmbH, Gothaer Strasse 39 99885 OHRDRUF Germany
  • PPUH Autopart Jacek Bąk Sp. z o.o., Kwiatkowskiego 2a 39-300 Mielec podkarpackie Poland
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 Box 5 B-1040 Brussels Belgium
  • Reagens Deutschland GmbH, Gewerbering 25 49393 Lohne Germany
  • S.I.A. Industria Accumulatori S.p.a., Via del Chiavicone, n°1 40051 Altedo (BO) Italy
  • SC ROMBAT SA / Bistrita / Romania, Drumul Cetatii Nr.6 - 420129 Bistrita Bistrita Nasaud Romania
  • Siapra SpA, Via A. Volta n 9 67051 AVEZZANO (AQ) Italy
  • SYSTEMS SUNLIGHT S.A., 2 Ermou & Nikis Street, Syntagma Square Neo Olvio 67 200 Xanthi Greece 105 63 Athens Attica Greece
  • Vipiemme s.p.a., SS11 Padana Superiore, 8 24040 Isso (Bergamo) Italy
  • ZAP Sznajder Batterien S.A., Warszawska 47 05-820 Piastów Poland
  • Baerlocher GmbH, Freisinger Str. 1 85716 Unterschleissheim Germany
  • UNION DERIVAN S.A, C/ Comte d´Urgell 240, 4D 08036 Barcelona Barcelona Spain

Other names

  • -
  • Lead oxide sulfate (Pb4O3(SO4))
  • tetrakis(lambda2-lead(2+)) trioxidandiide sulfate
  • Tetralead Trioxide Sulphate
  • Tetralead trioxide sulphate
  • Florstab TR
  • Tribasic lead sulfate
  • Tribasic lead sulphate

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Solid: particulate/powder (100%) [1]
C Substance type
Inorganic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
500 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
500 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
6.84 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
6.84

Vapour pressure

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
102 mg/L @ 20 °C and pH 8.77 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
102 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 47 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 47
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
1 553 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 28
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 42 studies submitted
  • 1 study processed
R log Kd
4.4 - 4.57 dimensionless @ 15 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence 18 2 19
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.4 µg/L (1)
Intermittent releases (freshwater) -
Marine water 3.3 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 µg/L (1)
Sediment (freshwater) 186 mg/kg sediment dw (1)
Sediment (marine water) 168 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 212 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 10.9 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 54 studies submitted
  • 46 studies processed
P/RResults
LC50 (49 days) 280.2 µg/L [1]
LC50 (4 days) 40.8 - 40 540 µg/L [72]
LC50 (48 h) 114 - 610 µg/L [4]
LC10 (49 days) 55.6 µg/L [1]
LC10 (4 days) 304.3 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 8
Weight of evidence 45
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 46 studies submitted
  • 30 studies processed
P/RResults
NOEC (3 months) 48 µg/L [1]
NOEC (84 days) 39.4 - 176.3 µg/L [2]
NOEC (62 days) 87 µg/L [1]
NOEC (60 days) 70 - 136 µg/L [2]
NOEC (53 days) 13.3 - 26.8 µg/L [3]

Type of Study provided
Studies with data
Key study 24
Supporting study 16
Weight of evidence 6
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 96 studies submitted
  • 66 studies processed
P/RResults
LC50 (4 days) 35 - 6 820 µg/L [53]
LC50 (48 h) 26 - 3 115.8 µg/L [42]
LC50 (24 h) 280 - 27 850 µg/L [2]
EC10 (72 h) 111.2 - 252.3 µg/L [4]
EC10 (48 h) 9.2 - 1 409.6 µg/L [7]

Type of Study provided
Studies with data
Key study 8
Supporting study 30
Weight of evidence 58
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 75 studies submitted
  • 49 studies processed
P/RResults
NOEC (4.2 months) 143.3 - 757.2 µg/L [2]
NOEC (4 months) 12 µg/L [1]
NOEC (56 days) 1 - 2.7 µg/L [4]
NOEC (42 days) 5.9 - 63 µg/L [4]
NOEC (34 days) 109 µg/L [1]

Type of Study provided
Studies with data
Key study 36
Supporting study 26
Weight of evidence 13
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 31 studies submitted
  • 9 studies processed
P/RResults
EC50 (72 h) 20.5 - 364 µg/L [15]
EC50 (48 h) 21.7 - 388 µg/L [8]
NOEC (4 days) 22.7 - 192.3 µg/L [2]
LOEC (4 days) 44.3 - 298.1 µg/L [2]
EC10 (4 days) 29.4 - 1 231.8 µg/L [4]

Type of Study provided
Studies with data
Key study 9
Supporting study 22
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (7 days) 1.07 - 8.53 µmol/L [7]
IC10 (7 days) 85 - 1 025 µg/L [6]
IC10 (7 days) 0.148 - 6.22 µmol/L [7]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 28 studies submitted
  • 3 studies processed
P/RResults
IC50 (9 h) 180 mg/L [1]
EC10 (24 h) 7 mg/L [1]
IC10 (24 h) 1 - 2.79 mg/L [3]
IC10 (60 min) 2.92 - 9.59 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 15 1
Weight of evidence 9
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
1 mg/L

Sediment toxicity

Study results
  • 16 studies submitted
  • 13 studies processed
P/RResults
NOEC (35 days) 1 699 mg/kg sediment dw [2]
NOEC (28 days) 503 - 4 719 mg/kg sediment dw [12]
NOEC (21 days) 1 126 - 2 903 mg/kg sediment dw [5]
NOEC (20 days) 3 390 - 5 230 mg/kg sediment dw [2]
LOEC (35 days) 2 734 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 13
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 17 studies submitted
  • 10 studies processed
P/RResults
NOEC (3.733 months) 130 - 564 mg/kg soil dw [3]
NOEC (56 days) 468 - 2 202 mg/kg soil dw [4]
NOEC (28 days) 400 - 6 078 mg/kg soil dw [6]
NOEC (21 days) 608 mg/kg soil dw [1]
EC10 (84 days) 2.03 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 9 1
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 8 studies submitted
  • 7 studies processed
P/RResults
NOEC (42 days) 400 - 3 000 mg/kg soil dw [3]
NOEC (36 days) 750 mg/kg soil dw [1]
NOEC (28 days) 34 - 7 020 mg/kg soil dw [6]
EC10 (35 days) 360 - 1 200 mg/kg soil dw [2]
EC10 (28 days) 193 - 4 718 mg/kg soil dw [19]

Type of Study provided
Studies with data
Key study 7
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 20 studies submitted
  • 15 studies processed
P/RResults
NOEC (4.433 months) 150 mg/kg soil dw [1]
NOEC (42 days) 150 - 287 mg/kg soil dw [2]
NOEC (30 days) 527 - 722 mg/kg soil dw [2]
NOEC (21 days) 374 - 7 190 mg/kg soil dw [8]
NOEC (5 days) 89 - 169 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 15
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 35 studies submitted
  • 22 studies processed
P/RResults
NOEC (1.726 years) 8.042 g/kg soil dw [2]
NOEC (1.534 years) 8.13 g/kg soil dw [2]
NOEC (10.033 months) 163 mg/kg soil dw [2]
NOEC (28 days) 100 - 810 mg/kg soil dw [4]
NOEC (21 days) 500 - 3 800 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 12
Supporting study 2 10
Weight of evidence 10
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 14 studies submitted
  • 14 studies processed
P/RResults
NOEC (7 months) 50 mg/kg diet [3]
NOEC (84 days) 25 - 2 000 mg/kg diet [7]
NOEC (75 days) 100 mg/kg diet [4]
NOEC (70 days) 200 mg/kg diet [1]
NOEC (60 days) 264 mg/kg diet [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 14
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg food

Toxicity to mammals

Study results
  • 13 studies submitted
  • 13 studies processed
P/RResults
NOEC (1.227 years) 550 mg/kg diet [2]
NOEC (1.159 years) 64 mg/kg diet [1]
NOEC (11.1 months) 512 mg/kg diet [1]
NOEC (6.3 months) 1 000 mg/kg diet [3]
NOEC (84 days) 1 000 mg/kg diet [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 13
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 8 studies submitted
  • 8 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [8]
M/CInterpretations of results
GHS criteria not met [2]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence 7
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (4 h) 5.05 mg/L air (rat) [1]
M/CInterpretations of results
Other [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Other [3]

dermal
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 5 000 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
LOAEL (rat): 200 ppm [1]
NOEL (rat): 0.002 mg/kg bw/day [1]
LOEL (rat): 0.005 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study 12 1
Weight of evidence 5
Other
Data waiving
no waivers
Study data: in vivo
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 5
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 9
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed NOAEL 7.8 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant