Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
231-943-8
CAS no.:
7779-88-6
Index number:
Molecular formula:
N2O6Zn
SMILES:
[Zn++].[O-]N(=O)=O.[O-]N(=O)=O
InChI:
InChI=1S/2NO3.Zn/c2*2-1(3)4;/q2*-1;+2
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
15
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance is very toxic to aquatic life, is toxic to aquatic life with long lasting effects, may intensify fire (oxidiser), is harmful if swallowed, causes serious eye damage, causes skin irritation and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is very toxic to aquatic life with long lasting effects.

Breakdown of all 300 C&L notifications submitted to ECHA

Acute Tox. 4 H302
Skin Irrit. 2 H315
STOT SE 3 H335
Ox. Sol. 2 H272
Aquatic Acute 1 H400
Aquatic Chronic 2 H411
Eye Dam. 1 H318
Eye Irrit. 2 H319
Aquatic Chronic 1 H410
Acute Tox. 3 H331
Ox. Liq. 2 H272
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 22 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fertilisers.

Other release to the environment of this substance is likely to occur from: outdoor use as reactive substance and indoor use as reactive substance.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), rubber (e.g. tyres, shoes, toys), wood (e.g. floors, furniture, toys) and plastic (e.g. food packaging and storage, toys, mobile phones). This substance is intended to be released from: packaging material for metal parts (releasing grease/corrosion inhibitors).

This substance is used in the following products: fertilisers, laboratory chemicals, perfumes and fragrances, cosmetics and personal care products, coating products and fillers, putties, plasters, modelling clay. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: agriculture, forestry and fishing, formulation of mixtures and/or re-packaging, scientific research and development and building & construction work. This substance is used for the manufacture of: fabricated metal products, machinery and vehicles and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, mixing in open batch processes and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: laboratory chemicals, fertilisers, pH regulators and water treatment products, coating products and cosmetics and personal care products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following products: laboratory chemicals, pH regulators and water treatment products and cosmetics and personal care products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance and in the production of articles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and as an intermediate step in further manufacturing of another substance (use of intermediates).

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: In case of major fire and large quantities: evacuate area and fight fire remotely due to the risk of explosion. Collect spillage. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • AGRONUTRITION, Parc Activestre 3 avenue de l'Orchidée 31390 CARBONNE France
  • Arysta Lifescience, ROUTE D'ARTIX BP 80 64150 Nogueres France France
  • B.C.FERTILIS,S.L., Albert Einstein 10 PI El Brosquill 46780 Oliva Valencia Spain
  • Bardyke Chemicals International Limited, 6th Floor, South Bank House Barrow Street D04 TR29 Dublin Ireland
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • CENTRUM METAL ODCZYNNIKI CHEMICZNE - MIDAS INVESTMENT SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ SP.K., ul. Opackiego 46A/11 05-090 Falenty Warszawa Poland
  • Chemetall GmbH, Trakehner Str. 3 60487 Frankfurt Germany
  • Chemetall Italia S.R.L., Via della Tecnica 5-7 I-20833 Giussano (MI) Italy
  • Chemetall S.A. Unipersonal, PS de la Ribera, 107 E-08420 Canovelles (Barcelona) Spain
  • Chemetall SAS, Carré 92, Immeuble G2, 8 avenue des Louvresses F-92622 Gennevilliers Cedex France
  • Cheminova A/S, Thyborønvej 78 7673 Harboøre Denmark
  • ExponentOR66I, Block 1, Blanchardstown Corporate Park Ballycoolin Road, Blanchardstown D15 AKK1 Dublin Ireland
  • Hanke + Seidel GmbH + Co.KG, Waldbadstr. 20 - 22 33803 Steinhagen NRW Germany
  • Houghton Italia S.p.A., Via P. Postiglione 30 - 10024 Moncalieri (Torino) Italy
  • Jinwang Europe, 218 Avenue Marie Curie Quai Jean Jaurès 07800 La Voulte sur Rhône France
  • Johnson Matthey Chemicals GmbH, Wardstrasse 17 D-46446 Emmerich am Rhein Germany
  • Lubrimetal SpA, Via Moggio, 19 23808 Vercurago Lecco Italy
  • Poletto Aldo S.r.l., Via Don Minzoni 13 30027 San Donà di Piave Italy
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • Przedsiębiorstwo Produkcyjno- Consultingowe ADOB Sp. z o.o., Kołodzieja 11 61-070 Poznań Poland Poland
  • TIB Chemicals AG, Muelheimer Str. 16-22 68219 Mannheim Germany
  • TRADE CORPORATION INTERNATIONAL S.A.U, Vía de los Poblados 3, Parque Empresarial Cristalia, Edif. Onic 5, 6th floor 28033 Madrid Spain
  • Johnson Matthey PLC, 5th Floor, 25 Farringdon Street EC4A 4AB London United Kingdom

Substance names and other identifiers

Celloxan
Other
Nitrate de zinc
Other
Nitric acid, zinc salt
Other
Nitric acid, zinc salt (2:1)
Other
X 4
Other
X 4 (nitrate)
Other
Zinc dinitrate
Other
Zinc nitrate
EC Inventory, REACH pre-registration, Other, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
ZINC NITRATE
REACH pre-registration, Other, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
Zinc nitrate (Zn(NO3)2)
Other
Zinc dinitrate
C&L Inventory, Registration dossier
Zinc nitrate
C&L Inventory, Registration dossier
Zinc Nitrate
C&L Inventory, Registration dossier
Zinc Nitrate Hexahydrate
C&L Inventory
Zinc Nitrato 6-hidrato
C&L Inventory
zinc(2+) dinitrate
Other
zinc(II) nitrate
C&L Inventory
zinc;dinitrate
Registration dossier, Other
zonc nitrate
C&L Inventory
Gardo Products
Registration dossier
10196-18-6
CAS number
C&L Inventory
22842-96-2
CAS number
Other
7779-88-6
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Powder (100%) [2]
C Odour
Odourless (100%) [2]
C Substance type
Inorganic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 2 studies processed
R Melting / freezing point
38.84 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
38.84 °C

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 2 studies submitted
  • 2 studies processed
R Relative density
1.054 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.054

Vapour pressure

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 20 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 2 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
998 g/L @ 22 °C and pH 6.96 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Water solubility
1 - 1 000 000 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 8
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
Oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
7.5 @ 23 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
pKa at 20 °C
7.5

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 90 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 86 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 36 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 25
Supporting study 10
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 14.4 - 41.7 µg/L (3)
Intermittent releases (freshwater) -
Marine water 6.1 - 20.9 µg/L (3)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 - 289.7 µg/L (3)
Sediment (freshwater) 117.8 - 425.5 mg/kg sediment dw (3)
Sediment (marine water) 60.5 - 469.8 mg/kg sediment dw (3)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil 35.6 - 240.7 mg/kg soil dw (3)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (3)

Short–term toxicity to fish

Study results
  • 34 studies submitted
  • 34 studies processed
P/RResults
LC50 (4 days) 102 - 35 980 µg/L [97]
LC50 (95 h) 330 µg/L [1]

Type of Study provided
Studies with data
Key study 32 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 59 studies submitted
  • 34 studies processed
P/RResults
NOEC (2.959 years) 530 - 534 µg/L [2]
NOEC (1.808 years) 130 µg/L [2]
NOEC (8 months) 78 - 575 µg/L [8]
NOEC (5 months) 50 - 130 µg/L [4]
NOEC (3.867 months) 56 - 250 µg/L [8]

Type of Study provided
Studies with data
Key study 23 11
Supporting study 6 3
Weight of evidence
Other 8 8
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 51 studies submitted
  • 34 studies processed
P/RResults
EC50 (48 h) 105 - 5 200 µg/L [40]
EC50 (24 h) 220 - 23 700 µg/L [12]
LC50 (48 h) 41 - 1 220 µg/L [42]
EC100 (48 h) 32 mg/L [1]
EC10 (48 h) 2.6 mg/L [1]

Type of Study provided
Studies with data
Key study 28 6
Supporting study 12 3
Weight of evidence
Other 1 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 202 studies submitted
  • 123 studies processed
P/RResults
NOEC (9 months) 33.3 - 100 µg/L [4]
NOEC (7 months) 100 µg/L [2]
NOEC (6 months) 100 µg/L [2]
NOEC (3.733 months) 72 - 75 µg/L [2]
NOEC (3 months) 300 µg/L [1]

Type of Study provided
Studies with data
Key study 70 53
Supporting study 43
Weight of evidence
Other 19 17
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 121 studies submitted
  • 34 studies processed
P/RResults
EC50 (10 days) 410 µg/L [1]
EC50 (4 days) 42 - 1 036 µg/L [7]
IC50 (72 h) 106 - 2 050 µg/L [9]
NOEC (16 days) 1.071 mg/L [2]
NOEC (10 days) 100 - 1 110 µg/L [2]

Type of Study provided
Studies with data
Key study 27 18
Supporting study 19
Weight of evidence
Other 30 27
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 11 studies submitted
  • 3 studies processed
P/RResults
EC50 (7 days) 76.73 mg/L [1]
NOEC (72 h) 60 µg/L [2]
EC10 (7 days) 1.31 - 2.12 mg/L [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 8 studies submitted
  • 4 studies processed
P/RResults
EC50 (3 h) 5.2 mg/L [2]
IC50 (4 h) 350 µg/L [2]
NOEC (4 h) 100 µg/L [2]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
100 µg/L

Sediment toxicity

Study results
  • 38 studies submitted
  • 22 studies processed
P/RResults
NOEC (1.055 years) 776 mg/kg sediment dw [2]
NOEC (7 months) 250 - 292.9 mg/kg sediment dw [2]
NOEC (56 days) 850 mg/kg sediment dw [2]
NOEC (42 days) 455 - 1 770 mg/kg sediment dw [10]
NOEC (35 days) 201 - 369 mg/kg sediment dw [4]

Type of Study provided
Studies with data
Key study 11 10
Supporting study 5 3
Weight of evidence 2 2
Other 4 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 33 studies submitted
  • 33 studies processed
P/RResults
NOEC (4.667 months) 181.8 mg/kg soil dw [1]
NOEC (56 days) 165 - 600 mg/kg soil dw [4]
NOEC (42 days) 195 - 1 767 mg/kg soil dw [8]
NOEC (28 days) 30 - 1 000 mg/kg soil dw [30]
NOEC (21 days) 85 - 566.8 mg/kg soil dw [26]

Type of Study provided
Studies with data
Key study 24 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 17 studies submitted
  • 17 studies processed
P/RResults
EC10 (42 days) 93 - 296.2 mg/kg soil dw [3]
EC10 (28 days) 14.6 - 1 261 mg/kg soil dw [23]
NOEC (42 days) 217 - 300 mg/kg soil dw [3]
NOEC (28 days) 32 - 1 000 mg/kg soil dw [26]

Type of Study provided
Studies with data
Key study 11 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 33 studies submitted
  • 21 studies processed
P/RResults
NOEC (5 months) 100 - 400 mg/kg soil dw [4]
NOEC (67 days) 300 mg/kg soil dw [1]
NOEC (65 days) 116.6 mg/kg soil dw [2]
NOEC (56 days) 200 mg/kg soil dw [4]
NOEC (48 days) 33 - 49.9 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 14 9
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 71 studies submitted
  • 56 studies processed
P/RResults
NOEC (6.067 months) 500 - 508 mg/kg soil dw [2]
NOEC (84 days) 17 - 200 mg/kg soil dw [6]
NOEC (63 days) 80 - 121 mg/kg soil dw [2]
NOEC (55 days) 50 - 198 mg/kg soil dw [8]
NOEC (52 days) 162 - 313 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 22 34
Supporting study 15
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 13 studies submitted
  • 8 studies processed
P/RResults
NOEC (5.133 months) 100 mg/kg diet [1]
NOEC (70 days) 131 mg/kg diet [3]
NOEC (42 days) 60 - 249 mg/kg diet [7]
NOEC (35 days) 240 mg/kg diet [2]
NOEC (28 days) 150 mg/kg bw [1]

Type of Study provided
Studies with data
Key study 8
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 8 studies submitted
  • 8 studies processed
P/RResults
NOEC (56 days) 400 mg/kg diet [1]
NOEC (42 days) 345.45 mg/kg diet [1]
NOEC (39 days) 347.5 mg/kg diet [1]
NOEC (35 days) 243 mg/kg diet [1]
NOEC (28 days) 2 000 - 3 000 mg/kg diet [3]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.3 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.25 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.3 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 830 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 57 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 47 4
Supporting study 5 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 9 5
Supporting study 5 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 13 studies submitted
  • 8 studies processed
P/RResults
LD50 300 - 2 280 mg/kg bw (rat) [9]
LD50 926 - 1 260 mg/kg bw (mouse) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [2]

Type of Study provided
oral
Studies with data
Key study 2 6
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 4 studies processed
P/RResults
LC50 (10 min) 1.975 mg/L air (rat) [2]
M/CInterpretations of results
Harmful [2]

inhalation
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study 2 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed LD50 300 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irreversible damage)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 30 studies submitted
  • 6 studies processed
P/RResults
NOAEL (rat): 31.25 - 31.52 mg/kg bw/day [2]
LOAEL (rat): 53.8 - 125 mg/kg bw/day [3]
NOEL (rat): 3 000 ppm [1]
NOEL (mouse): 3 000 ppm [1]
LOEL (rat): 30 000 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 16 7
Weight of evidence 3
Other 1
Data waiving
no waivers
Study data: inhalation
  • 21 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 1.5 mg/m³ air [1]
NOAEC (rat): 470 - 500 µg/m³ air [2]
LOAEC (rat): 4.45 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 3 2
Supporting study 12 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 13.3 mg/kg bw/day (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 1.48 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 53 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2 1 4
Supporting study 1 16
Weight of evidence 19
Other 10
Data waiving
no waivers
Study data: in vivo
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 10
Weight of evidence 7
Other 6
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 2
Supporting study 5 1
Weight of evidence
Other 5
Data waiving
no waivers
Study data: developmental
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 1 4
Supporting study 3 2
Weight of evidence 6
Other 2
Data waiving
no waivers
Study data: other studies
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 12 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 7.5 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant