Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
229-352-5
CAS no.:
6485-40-1
Index number:
606-148-00-8
Molecular formula:
C10H14O
SMILES:
CC(=C)[C@@H]1CC=C(C)C(=O)C1
InChI:
InChI=1/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/s2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP07) approved by the European Union, this substance may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful if swallowed.

Breakdown of all 2066 C&L notifications submitted to ECHA

Skin Sens. 1 H317 Harmonised Classification
Acute Tox. 4 H302
Skin Sens. 1B H317
Eye Irrit. 2A H319
Skin Irrit. 2 H315
STOT SE 3 H335
Aquatic Chronic 3 H412
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (50% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 6 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

This substance is used in the following products: air care products, polishes and waxes, biocides (e.g. disinfectants, pest control products), perfumes and fragrances, cosmetics and personal care products, washing & cleaning products and pharmaceuticals.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys). This substance is intended to be released from scented: clothes, eraser, toys, paper products and CDs.

This substance is used in the following products: washing & cleaning products and polishes and waxes.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications and non-industrial spraying.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

This substance is used in the following products: perfumes and fragrances, air care products, biocides (e.g. disinfectants, pest control products), polishes and waxes, washing & cleaning products and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: washing & cleaning products.

This substance is used for the manufacture of: chemicals and .

This substance is used in the following activities or processes at workplace: transfer of chemicals, industrial spraying, batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid breathing the dust, fume, gas, mist, vapours or spray; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • Ramboll Deutschland GmbH, Werinherstr. 79 Gebäude 32a 81541 München Germany
  • Symrise AG, Mühlenfeldstraße 1 37603 Holzminden Germany
  • WANXIANG IRELAND FLAVORS & FRAGRANCES CO., LIMITED, 302, THE CAPEL BUILDING, MARY’S ABBEY Dublin 7 Dublin Ireland

Substance names and other identifiers

(-)-Carvone
Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys
(5R)-2-Methyl-5-prop-1-en-2-ylcyclohex-2-en-l-one
Cosmetic Products Regulation, Annex III - Restricted Substances
(R)-2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-one
Other
(R)-Carvone
Other
2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (5R)-
Other
2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (R)- (9CI)
Other
2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (theta)-
Other
Carvone, (-)-
Other
l-Carvone
Other
l-Carvone (natural)
Other
l-carvone; (5R)-2-methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-one
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
l-carvone; (5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
C&L Inventory
L-p-mentha-1(6),8-dien-2-one
EC Inventory, REACH pre-registration
l-p-Mentha-1(6),8-dien-2-one
REACH pre-registration, Other
p-Mentha-6,8-dien-2-one, (-)-
Other
p-Mentha-6,8-dien-2-one, (R)-(-)-
Other
l -καρβόνη; (5R)-2-μεθυλ-5- (προπ-1-εν-2-υλο) κυκλοεξ-2-εν- 1-όνη (el)
C&L Inventory
l-Carvon; (5R)-2-Methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-on (de)
C&L Inventory
l-carvon; (5R)-2-methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-on (nl)
C&L Inventory
l-carvon; (5S)-2-methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-on (da)
C&L Inventory
l-carvone; (5R)-2- metil -5- (prop-1-en-2-il) cicloes -2-en- 1-one (it)
C&L Inventory
l-carvone; (5R)-2-metil-5- (prop-1-en-2-il)ciclo-hex- 2-en-1-ona (pt)
C&L Inventory
l-carvone; (5R)-2-metil-5- (prop-1-en-2-il)ciclohex-2-en- 1-ona (es)
C&L Inventory
l-carvone; (5R)-2-méthyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-one (fr)
C&L Inventory
l-carvonă; (5R)-2-metil-5-(prop- 1-en-2-il)ciclohex -2-en-1-onă (ro)
C&L Inventory
L-karvon; (5R)-2-methyl-5- (prop-1-en-2-yl)cyklohex-2-en- 1-on (cs)
C&L Inventory
l-karvon; (5R)-2-metil-5- (prop-1-en-2-il)cikloheks-2- en-1-on (sl)
C&L Inventory
l-karvon; (5R)-2-metil-5-(prop- 1-en-2-il)-ciklohex-2-en-1- on (hu)
C&L Inventory
l-karvon; (5R)-2-metil-5-(prop- 1-en-2-il)cikloheks-2-en-1- on (hr)
C&L Inventory
l-karvon; (5R)-2-metyl-5- (prop-1-en-2-yl)cyklohex-2-en- 1-on (sv)
C&L Inventory
l-karvon; (5S)-2-metil-5- (prop-1-en-2-il)ċikloħessi-2- en-1-on (mt)
C&L Inventory
l-karvonas; (5R)-2-metil-5- (prop-1-en-2-il)cikloheks-2- en-1-onas (lt)
C&L Inventory
l-karvoni; (5R)-2-metyyli-5- (prop-1-en-2-yyli)sykloheks-2- en-1-oni (fi)
C&L Inventory
l-karvons; (5R)-2-metil-5- (prop-1-en-2-il)cikloheks-2-en- 1-ons (lv)
C&L Inventory
l-karvoon; (5R)-2-metüül-5- (prop-1-een-2-üül)tsükloheks- 2-een-1-oon (et)
C&L Inventory
L-karvón; 5-izopropenyl-2-metylcyklohex-2-én-1-ón (sk)
C&L Inventory
l-karwon; (5R)-2-metylo-5- (prop-1-en-2-ylo)cykloheks-2- en-1-on (pl)
C&L Inventory
l-карвон; (5R)-2-метил-5-(проп- 1-ен-2-ил)циклохекс-2-ен-1-он (bg)
C&L Inventory
(5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
C&L Inventory, Other
(5R)-2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one
C&L Inventory, Other
(5R)-2-metil-prop-1-es-2-iliciclohex-2-en-1-on
C&L Inventory
(R)-(-)-Carvone
C&L Inventory
- (5R)-2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one
C&L Inventory
2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (5R)-
C&L Inventory
2-METHYL-5-(1-METHYLETHENYL)CYCLOHEX-2-EN-1-ONE
C&L Inventory
5-Isopropenyl-2-methylcyclohex-2-en-1-one
C&L Inventory, Registration dossier
Carvone
Registration dossier
l carvone
C&L Inventory
L-Carvone
Registration dossier
l-Carvone, laevo-Carvone, l-p-Mentha-1(6),8-dien-2-one
Registration dossier
l-carvone; (5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
C&L Inventory
L-p-Mentha-1(6),8-dien-2-one
C&L Inventory, Registration dossier
L-p-mentha-1(6),8-dien-2-one
Registration dossier
Carvone
Registration dossier
CARVONE LAEVO
C&L Inventory
L-carvone
Registration dossier
606-148-00-8
Index number
C&L Inventory
6485-40-1
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 11 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [4]
C Form
Liquid (100%) [2]
C Odour
Other (100%) [2]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)
Form
Liquid (100%)
Colour
colourless (100%)

Melting/freezing point

Study results
  • 7 studies submitted
  • 4 studies processed
R Melting / freezing point
-8.17 - 25.2 °C @ 96.79 kPa [4]

Type of Study provided
Studies with data
Key study 2 1 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Melting / freezing point at 101 325 Pa
-8.17 - 25.2 °C

Boiling point

Study results
  • 9 studies submitted
  • 4 studies processed
R Boiling point
230 - 231.9 °C @ 97.24 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Boiling point at 101 325 Pa
230 - 231.9 °C

Density

Study results
  • 9 studies submitted
  • 4 studies processed
R Density
0.947 - 0.96 g/cm³ @ 20 °C [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Relative density at 20°C
0.947 - 0.96

Vapour pressure

Study results
  • 7 studies submitted
  • 4 studies processed
R Vapour pressure
15.332 - 50 Pa @ 20 - 25 °C [4]

Type of Study provided
Studies with data
Key study 2 1 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Vapour pressure
15.3 - 50 Pa @ 20 - 25 °C

Partition coefficient

Study results
  • 12 studies submitted
  • 4 studies processed
R Log Pow
2.71 - 2.74 @ 37 °C and pH 7.2 [5]

Type of Study provided
Studies with data
Key study 4
Supporting study 7 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Log Kow (Log Pow)
2.74 @ 20 - 37 °C

Water solubility

Study results
  • 6 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
47.2 - 1 300 mg/L @ 14 - 25 °C [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence 1 2
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Water solubility
47.2 - 1 300 mg/L @ 14 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
29.8 mN/m

Flash point

Study results
  • 6 studies submitted
  • 3 studies processed
R Flash point
92 - 97.6 °C @ 97.24 kPa [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Flash point at 101 325 Pa
92 - 97.6 °C

Auto flammability

Study results
  • 4 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
292 °C @ 99.98 kPa [2]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
292 °C

Flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Flammability
Not classified (75%), Non flammable (25%)

Explosiveness

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Oxidising
Non oxidising (75%), No (25%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 4 studies submitted
  • 3 studies processed
R dynamic viscosity (in mPa s)
16.145 - 20.319 [2]
R kinematic viscosity (in mm²/s)
2.722 - 21.463 [4]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Static viscosity at 20 °C
2.72 - 17.054 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 12 studies submitted
  • 7 studies processed
C Interpretation of results
Readily biodegradable (100%) [7]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4
Weight of evidence 5
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life in freshwater
15 days @ 25 °C
Half-life in freshwater sediment
4.5 months @ 25 °C

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life in soil
30 days @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 12
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
28.51 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 10 studies submitted
  • 5 studies processed
R Koc
136.2 - 1 100 dimensionless @ 25 °C [4]
R log Koc
2.795 dimensionless @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 2 5
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Koc at 20°C
136.2

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 6.1 - 67 µg/L (4)
Intermittent releases (freshwater) 61 - 670 µg/L (4)
Marine water 610 - 6 700 ng/L (4)
Intermittent releases (marine water) 6.1 - 67 µg/L (3)
Sewage treatment plant (STP) 10 - 100 mg/L (3)
Sediment (freshwater) 192 - 1 150 µg/kg sediment dw (4)
Sediment (marine water) 19 - 115 µg/kg sediment dw (4)
Hazard for Air
Air No hazard identified (4)
Hazard for Terrestrial Organism
Soil 34.8 - 191 µg/kg soil dw (4)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (4)

Short–term toxicity to fish

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
LC50 (4 days) 1.1 - 107.721 mg/L [6]
LC100 (4 days) 100 mg/L [1]
NOEC (4 days) 4.5 mg/L [2]
LOEC (4 days) 8.4 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 6 2
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 12 studies submitted
  • 5 studies processed
P/RResults
EC50 (48 h) 17 - 38 mg/L [5]
EC0 (48 h) 20 mg/L [2]
EC100 (48 h) 70 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 5 studies processed
P/RResults
EC50 (72 h) 19 - 710 mg/L [6]
NOEC (72 h) 4.3 - 160 mg/L [4]
LOEC (72 h) 14 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 4 1
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
EC50 for freshwater algae
19 - 178.844 mg/L
EC10 or NOEC for freshwater algae
4.3 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
75 mg/L
EC10 or NOEC for freshwater plants
10 mg/L

Toxicity to microorganisms

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
1 g/L
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 685 µg/m³ developmental toxicity / teratogenicity
Acute /short term: Medium hazard (no threshold derived)
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 194 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (High hazard (no threshold derived)) -
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 121 µg/m³ developmental toxicity / teratogenicity
Acute /short term: Medium hazard (no threshold derived)
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 69.4 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (High hazard (no threshold derived)) -
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 69.4 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 11 studies submitted
  • 7 studies processed
P/RResults
LD50 1 640 - 5 900 mg/kg bw (rat) [10]
LD50 1 720 mg/kg bw (mouse) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [5]

Type of Study provided
oral
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence 4 1
Other
Data waiving
no waivers
inhalation
  • 7 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 6.45 mg/L air (rat) [1]
M/CInterpretations of results
Other [1]

inhalation
Studies with data
Key study
Supporting study
Weight of evidence 4 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
dermal
  • 7 studies submitted
  • 7 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
LD50 3 076 - 5 000 mg/kg bw (rabbit) [5]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 1 1
Supporting study
Weight of evidence 4 1
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Oral route:
Adverse effect observed LD50 1 640 mg/kg bw
Inhalation route:
No adverse effect observed LC50 5.66 mg/L air
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 1
Weight of evidence 10
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Study data: eye
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1 1
Supporting study
Weight of evidence 4 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3 1
Supporting study 24
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 11 studies submitted
  • 6 studies processed
P/RResults
NOAEL (rat): 723 mg/kg bw/day [1]
NOAEL (mouse): 375 - 750 mg/kg bw/day [3]
NOAEL (mouse): 375 mg/kg bw (total dose) [2]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence 5 3 1
Other
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 723 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 5 3
Supporting study 7 1
Weight of evidence 3 1
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3
Supporting study 8
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 125 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed LOAEL 125 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant