Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
220-239-6
CAS no.:
2682-20-4
Index number:
Molecular formula:
C4H5NOS
SMILES:
CN1SC=CC1=O
InChI:
InChI=1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
4
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance is fatal if inhaled, is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, causes serious eye damage and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is fatal in contact with skin, may cause damage to organs through prolonged or repeated exposure and may cause respiratory irritation.

Breakdown of all 2313 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Skin Sens. 1 H317
Acute Tox. 3 H301 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Eye Dam. 1 H318 Harmonised Classification
STOT SE 3 H335
Aquatic Chronic 1 H410 Harmonised Classification
Acute Tox. 4 H302
Acute Tox. 2 H330 Harmonised Classification
Acute Tox. 3 H331
Skin Sens. 1A H317 Harmonised Classification
Acute Tox. 4 H332
STOT RE 2 H373
Acute Tox. 2 H310
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 4 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 0 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 - 100 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved for use as a biocide in the EEA and/or Switzerland, for: preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.

This substance is being reviewed for use as a biocide in the EEA and/or Switzerland, for: product preservation.

This substance is used in the following products: cosmetics and personal care products, fertilisers, plant protection products and perfumes and fragrances.

Other release to the environment of this substance is likely to occur from: outdoor use as processing aid and indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: laboratory chemicals, fertilisers, plant protection products, perfumes and fragrances, cosmetics and personal care products and pH regulators and water treatment products.

This substance is used in the following areas: agriculture, forestry and fishing, health services and scientific research and development.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, mixing in open batch processes, laboratory work, non-industrial spraying and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: laboratory chemicals, fertilisers, plant protection products, perfumes and fragrances, cosmetics and personal care products and biocides (e.g. disinfectants, pest control products).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals.

This substance is used in the following areas: health services and scientific research and development. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, transfer of substance into small containers, laboratory work and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Specialty Electronic Materials Belgium, BV, Rue Jules Bordet 7180 Seneffe Belgium
  • Specialty Electronic Materials Netherlands BV OR-6, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • THOR GmbH, Landwehrstrasse 1 D-67346 Speyer Rheinland-Pfalz Germany

Substance names and other identifiers

2-methyl-2H-isothiazol-3-one
EC Inventory, REACH pre-registration, EU. Cosmetics Regulation Annex V, Allowed Preservatives
2-methyl-4-isothiazolin-3-one
EU. Com. Reg. No 10/2011 on plastic materials in contact with food
2-methylisothiazol-3(2H)-one
C&L Inventory, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
2-methylisothiazolin-3(2H)-one
EU. Substances Restricted in Toy
Methylisothiazolinone
Other
2-methyl-2H-isothiazol-3-on (MIT) (da)
Biocidal active substances
2-methyl-2H-isothiazol-3-one (MIT) (mt)
Biocidal active substances
2-Methyl-2H-isothiazool-3-on (MIT) (nl)
Biocidal active substances
2-methyltetrahydroisothiazol-3(2H)-on (MIT) (cs)
Biocidal active substances
2-Metil-2H-isotiazol-3-ona (MIT) (es)
Biocidal active substances
2-metil-2H-isotiazol-3-one (MIT) (it)
Biocidal active substances
2-metil-2H-isotiazol-3-onă (MIT) (ro)
Biocidal active substances
2-metil-2H-izotiazol-3-on (MIT) (hr)
Biocidal active substances
2-metil-2H-izotiazol-3-onas (MIT) (lt)
Biocidal active substances
2-Metil-2H-izotiazol-3-ons (MIT) (lv)
Biocidal active substances
2-metyl-2H-isotiazol-3-on (MIT) (sv)
Biocidal active substances
2-metyl-2H-izotiazol-3-ón (MIT) (sk)
Biocidal active substances
2-metylo-2H-izotiazol-3-on (MIT) (pl)
Biocidal active substances
2-metyyli-2H-isotiatsol-3-oni (MIT) (fi)
Biocidal active substances
2-metüül-2H-isotiasool-3-oon (MIT) (et)
Biocidal active substances
2-méthyl-2H-isothiazole-3-one (MIT) (fr)
Biocidal active substances
2-Μεθυλ-2H-ισοδιαζολ-3-όνη (MIT) (el)
Biocidal active substances
2-метил-2H-изотиазол-3-он (MIT) (bg)
Biocidal active substances
2-Methyl-1,2-thiazol-3(2H)-one
C&L Inventory
2-methyl-1,2-thiazol-3-one
C&L Inventory, Other
2-methyl-1,2-thiazol-3-one hydrochloride
C&L Inventory
2-methyl-2,3-dihydro-1,2-thiazol-3-one
Other
2-Methyl-3(2H)-isothiazolon
C&L Inventory
2-Methyl-3(2H)-isothiazolone
C&L Inventory, Registration dossier
2-methyl-4- isothiazolin-3-one
C&L Inventory
2-Methyl-4-isothiazol-3-one
C&L Inventory
2-Methylisothiazolin-3-one
C&L Inventory
3(2H) -Isothiazolone, 2-methyl-
C&L Inventory
3(2H)-Isothiazolone, 2-methyl-
C&L Inventory
Kordek™ 573T biocide dry material
Registration dossier
Syntomast
C&L Inventory
125794-71-0
CAS number
Other
1610617-47-4
CAS number
Other
184720-17-0
CAS number
Other
2682-20-4
CAS number
EC Inventory, C&L Inventory, Biocidal active substances, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation Annex V, Allowed Preservatives, EU. Dangerous Substances - Eco-Labels, EU. Com. Reg. No 10/2011 on plastic materials in contact with food, EU. Workplace Signs, EU. Substances Restricted in Toy, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
613-326-00-9
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Other (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 2 studies processed
R Melting / freezing point
39 - 48.3 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
47.5 °C

Boiling point

Study results
  • 3 studies submitted
  • 1 study processed
R Boiling point
130 °C @ 16 hPa [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
130 °C

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Density
1.39 g/cm³ @ 20 °C [1]
R Relative density
1.39 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.39

Vapour pressure

Study results
  • 3 studies submitted
  • 2 studies processed
R Vapour pressure
0.408 - 1.6 Pa @ 20 - 25 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0.73 Pa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 2 studies processed
R Log Pow
-0.486 - -0.26 @ 10 - 30 °C and pH 5 - 9 [6]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-0.486 @ 20 °C

Water solubility

Study results
  • 4 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
489 - 1 000 g/L @ 10 - 30 °C and pH 5 - 9 [5]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
489 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Solubility in mg/100g standard fat at 20 °C
0.93

Surface tension

Study results
  • 2 studies submitted
  • 2 studies processed
R Surface tension
68.8 - 72.32 mN/m @ 1 - 1.01 g/L and 19.5 - 20.1 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 5 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
396 °C @ 101.2 kPa [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 2 studies submitted
  • 2 studies processed
R pH
2.58 @ 25 °C and 50 g/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
13 - 14.35 h [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
14.35 h
Degradation rate constant with OH radicals
2 318 976 000 000 000 000 000 000 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
1 years @ 25 °C

Phototransformation in water

Study results
  • 4 studies submitted
  • 1 study processed
R Dissipation Half-life (DT50)
18.2 days [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
11 days

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 3.39 µg/L (1)
Intermittent releases (freshwater) 3.39 µg/L (1)
Marine water 3.39 µg/L (1)
Intermittent releases (marine water) 3.39 µg/L (1)
Sewage treatment plant (STP) 230 µg/L (1)
Sediment (freshwater) No hazard identified (1)
Sediment (marine water) No hazard identified (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 47.1 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 4.77 - 6 mg/L [2]
LC50 (72 h) 6 mg/L [1]
LC50 (48 h) 6.2 mg/L [1]
LC50 (24 h) 7.3 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
4.77 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (3.267 months) 2.38 - 4.93 mg/L [2]
NOEC (33 days) 2.1 - 8.5 mg/L [4]
LOEC (3.267 months) 4.93 - 9.88 mg/L [2]
LOEC (33 days) 4.2 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
4.93 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 1.6 mg/L [1]
EC50 (24 h) 1.7 mg/L [1]
LC50 (4 days) 1.81 mg/L [1]
LC50 (48 h) 934 µg/L [1]
NOEC (4 days) 1.3 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
934 µg/L
EC50 / LC50 for marine invertebrates
2.98 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 44.2 - 550 µg/L [2]
LOEC (21 days) 88.9 - 1 100 µg/L [2]
EC50 (21 days) 1.4 - 1.6 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
44.2 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
EC50 (5 days) 138 - 220 µg/L [2]
EC50 (4 days) 63 - 72.5 µg/L [4]
EC50 (24 h) 445 µg/L [1]
NOEC (5 days) 50 µg/L [1]
NOEC (4 days) 10 - 120 µg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
103 µg/L
EC50 for marine water algae
72.5 µg/L
EC10 or NOEC for freshwater algae
50.3 µg/L
EC10 or NOEC for marine water algae
72.5 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (16 h) 2.3 mg/L [1]
EC50 (3 h) 41 mg/L [1]
EC10 (16 h) 1 mg/L [1]
EC100 (16 h) 16 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
41 mg/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 13 - 25 mg/kg sediment dw [2]
LOEC (28 days) 25 - 50 mg/kg sediment dw [2]
EC50 (28 days) 100 mg/kg sediment dw [1]
LC50 (28 days) 34.9 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
50 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
25 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 21 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 43 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: (Medium hazard (no threshold derived)) -
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 21 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 43 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: (Medium hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 27 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 53 µg/kg bw/day repeated dose toxicity
EYE Exposure
High hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 3 studies processed
P/RResults
LD50 120 - 327.7 mg/kg bw (rat) [6]
M/CInterpretations of results
Category 3 based on GHS criteria [2]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 100 - 422 mg/m³ air (rat) [6]
M/CInterpretations of results
Category 2 based on GHS criteria [1]

inhalation
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 242 - 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 120 mg/kg bw
Inhalation route:
Adverse effect observed LC50 340 µg/m³
Dermal route:
Adverse effect observed LD50 242 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irreversible damage)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 19 - 30.09 mg/kg bw/day [4]
NOAEL (dog): 40.6 - 40.9 mg/kg bw/day [1]
LOAEL (rat): 71.2 mg/kg bw/day [1]
NOEL (dog): 9.9 - 11.1 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 19 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 3.1 mg/kg bw/day (chronic, rat)
Dermal route:
No adverse effect observed NOAEL 400 mg/kg bw/day (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 69 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 30 mg/kg bw/day (chronic, rabbit)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant