Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-143-3
CAS no.:
78-79-5
Index number:
601-014-00-5
Molecular formula:
C5H8
SMILES:
CC(=C)C=C
InChI:
InChI=1S/C5H8/c1-4-5(2)3/h4H,1-2H2,3H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
18
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may cause cancer, is an extremely flammable liquid and vapour, is suspected of causing genetic defects and is harmful to aquatic life with long lasting effects.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 2422 C&L notifications submitted to ECHA

Flam. Liq. 1 H224 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Muta. 2 H341 Harmonised Classification
Aquatic Chronic 3 H412 Harmonised Classification
Aquatic Chronic 2 H411
Eye Irrit. 2 H319
Asp. Tox. 1 H304
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (100% of REACH registrations).
  • M
Suspected to be Mutagenic (Harmonised C&L).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 77 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, manufacturing of the substance, formulation of mixtures, formulation in materials, in processing aids at industrial sites, in the production of articles, as processing aid, as processing aid and of substances in closed systems with minimal release.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals.

This substance is used in the following areas: health services and scientific research and development.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and in materials as fuel sources, with limited exposure to unburned product to be expected.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, manufacturing of the substance, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following products: pH regulators and water treatment products, laboratory chemicals and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures, formulation in materials, in processing aids at industrial sites, in the production of articles, as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; do not handle until all safety precautions have been read and understood; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If exposed or concerned: get medical advice/attention.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • 3M Deutschland GmbH, Carl-Schurz-Strasse 1 41453 Neuss Germany
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • Anthesis (Ireland) Limited 27, The Black Church St. Mary's Place D07 P4AX Dublin Ireland
  • ARLANXEO Deutschland GmbH, Alte Heerstraße 2 41540 Dormagen Germany
  • ARLANXEO Netherlands B.V. (OR for Canada), Urmonderbaan 24 6167 RD Geleen Netherlands
  • ARLANXEO Netherlands B.V. (OR for Singapore), Urmonderbaan 24 6167 RD Geleen Netherlands
  • B-Lands Consulting (8111161-7), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • BD&I_37, rue Omer Lepreux, 92 1081 bruxelles Belgium Belgium
  • Bostik Nederland B.V._01, Zeggeveld #10 RP4705 Roosendaal Netherlands
  • Braskem Netherlands B.V., Weena 00240, C 9th floor NL - 3012 NJ PO Box 30128 3001 DC Rotterdam Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemservice GmbH - (R2S5), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chevron Phillips Chemicals International NV, Airport Plaza, Stockholm Building, Da Vincilaan 19 B-1831 DIEGEM Belgium
  • CNP Polymer GmbH, schultessdamm 58 22391 hamburg hamburg Germany
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Canada Co.\Cie, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • Daschi Chemie B.V., Molendijk-Zuid 5482WZ Schijndel Netherlands
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany
  • DuPont Specialty Products GmbH & Co. KG, Hugenottenallee 175 63263 Neu-Isenburg Hesse Germany
  • ExxonMobil Chemical France SARL, 20 Rue Paul Heroult 92000 Nanterre France
  • ExxonMobil Petroleum & Chemical BV, Polderdijkweg 2030 Antwerpen Belgium
  • Goodyear Operations S.A., Avenue Gordon Smith L-7750 Colmar-Berg Luxembourg
  • Goodyear SA, Avenue Gordon Smith L-7750 Colmar-Berg Luxembourg
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HH Compliance Ltd., Rubicon Building, CIT Campus Bishopstown none Cork Ireland
  • HH Compliance Ltd., The Rubicon Centre, CIT Campus, 0000 Bishopstown, Cork Ireland
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Innospec Performance Chemicals France SAS (Only Rep 7), Boite Postale 19 Han-sur-Meuse F-55300 St. Mihiel Meuse France
  • Intertek Deutschland GmbH CTNI, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH DEX, Stangenstrasse 1 70771 Leinfelden-Echterdingen Baden-Württemberg Germany
  • Intertek Deutschland GmbH TTRT, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Kuraray Europe GmbH (OR2), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Labcorp Development SA 042, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 066, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 067, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 173, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 183, Parque Empresarial Las Tablas, Edificio 1Calle Federico Mompou, 5 – 5 28050 Madrid Spain
  • LANXESS Organometallics GmbH, Justus-von-Liebig Str. 1620 59192 Bergkamen 05 Germany
  • LISAM TELEGIS, Parc d'activités de Noyon-Passel 17 rue de la Couture 60400 PASSEL France
  • Luxcontrol S.A. (OR18), 1, Avenue des Terres Rouges - 4004 Esch-sur-Alzette - Luxembourg
  • Manufacture Française des Pneumatiques Michelin (OR CAN), Place des Carmes Déchaux 63040 Clermont Ferrand France
  • Manufacture Française des Pneumatiques Michelin (OR US), Place des Carmes Déchaux 63040 Clemront Ferrand France
  • MFPM Only representative for Michelin Shenyang Tire Co., Ltd., Place des Carmes Déchaux 63040 Clermont-Ferrand France
  • MFPM Only Representative for SOCIEDADE MICHELIN DE PARTICIPAÇÕES INDÚSTRIA E COMÉRCIO LTDA, Place des Carmes Déchaux 63040 Clermont-Ferrand France
  • MFPM Only Representative pour Michelin India Tamilnadu Tyres Private Limited, Place des Carmes Déchaux Site de Ladoux - Batiment G22 63040 Clermont-Ferrand France
  • Mitsui and Co. Benelux S.A./N.V., Treurenberg 2 1000 Brussels Belgium
  • Only representative (No publishable name), null
  • POLYNT S.p.A., via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H Consulting Group, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACHLaw Ltd, Aleksanterinkatu 19 00100 Helsinki Finland
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21, FI-02600 Espoo Finland Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Regartis s.r.o., Rubeška 393/7 19000 Praha 9 Czech Republic
  • Savarè I.C. S.r.l., via Polidoro da Caravaggio 3 20156 Milano Lombardia Italy
  • Semperit Technische Produkte Ges. m. b. H. , Modecenterstrasse 22 1030 Wien Austria
  • Shell Chemicals Europe B.V., Weena 505 3013 AL Rotterdam Netherlands Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Sinopec Europa GmbH, Messe Turm, Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • THK RHYTHM AUTOMOTIVE CZECH a.s., Strojírenská 160 38017 Dačice Czech Republic
  • Tyco Electronics Raychem GmbH, Finsinger Feld 1 85521 Ottobrunn Bayern Germany
  • Tyre Company Dębica SA., 1Maja 1 39-200 Dębica Poland
  • TÜV SÜD Iberia S.A.U. (046), Ronda Can Fatjó 13 Parc Tecnològic del Vallès 08290 Cerdanyola del Vallès Barcelona Spain
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • [Confidential], [Confidential]
  • Avery Dennison België bvba STD, Tieblokkenlaan 1 2300 Turnhout Belgium
  • ConvaTec Ltd, GDC First Avenue Deeside Industrial Park CH5 2NU Deeside Flintshire United Kingdom
  • DEKRA Assurance Services GmbH OR01, Handwerkstr. 15 70565 Stuttgart Germany
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • ExxonMobil Chemical Ltd., Ermyn Way ExxonMobil House KT22 8UX Surrey Leatherhead United Kingdom
  • Henkel AG & Co. KGaA, Henkelstrasse 67 40191 Duesseldorf North-Rhine Westfalia Germany
  • Henkel Ltd., Wood Lane End HP2 4RQ Hemel Hempstead, United Kingdom
  • Henkel Nederland B.V., Brugwal 11 3432 NZ Nieuwegein Netherlands
  • Henkel Sweden Operations AB, Torsgatan 12 PO Box 12033 600-12 Norrkoping Sweden
  • K&K Elastomere GmbH, Dorfstraße 18 D-22955 Hoisdorf Schleswig-Holstein Germany
  • Luxcontrol S.A. (OR19), 1, Avenue des Terres Rouges 4004 Esch-sur-Alzette Luxembourg
  • NetSun EU B.V., Blaak 40, Fifth Floor 3011 TA Rotterdam Netherlands

Substance names and other identifiers

1,3-Butadiene, 2-methyl-
Other
2-Methyl-1,3-butadiene
Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
2-Methylbutadiene
Other
2-Methyldivinyl
Other
3-Methyl-1,3-butadiene
Other
beta-Methylbivinyl
Other
Isopentadiene
Other
Isoprene
EC Inventory, REACH pre-registration, Other
Isoprene
REACH pre-registration, Other, Ambient Air Quality Directive, Annex X - Ozone Precursor Substances
isoprene (stabilised) 2-methyl-1,3-butadiene
C&L Inventory
isoprene (stabilised); 2-methyl-1,3-butadiene
FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
Isoprene (stabilized)
Cosmetic Products Regulation, Annex II - Prohibited Substances
ISOPRENE, STABILIZED
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
isopreen (nl)
C&L Inventory
Isopreen (stabiliseeritud) 2-metüül-1,3-butadieen (et)
C&L Inventory
isopreeni 2-metyyli-1,3-butadieeni (fi)
C&L Inventory
isopren (stabilisert) 2-metyl-1,3-butadien (no)
C&L Inventory
Isopren (stabilisiert) 2-Methyl-1,3-butadien (de)
C&L Inventory
isopren (stabilizovaný) 2-methylbuta-1,3-dien (cs)
C&L Inventory
isopren 2-methyl-1,3-butadien (da)
C&L Inventory
isopren 2-metyl-1,3-butadien (sv)
C&L Inventory
isoprene 2-metil-1,3-butadiene (it)
C&L Inventory
isopreno (estabilizado) 2-metil-1,3-butadieno (pt)
C&L Inventory
isopreno 2-metil-1,3-butadieno (es)
C&L Inventory
isoprène (stabilisé)2-méthyl-1,3-butadiène 2-méthyl-1,3-butadiène (fr)
C&L Inventory
izopren 2-metil-1,3-butadien (sl)
C&L Inventory
izopren 2-metylobuta-1,3-dien (pl)
C&L Inventory
izopren(stabilizat) 2-metil-1,3-butadiena (ro)
C&L Inventory
izoprenas (stabilus) 2-metil-1,3-butadienas (lt)
C&L Inventory
izoprén (stabilizovaný) 2-metylbuta-1,3-dién (sk)
C&L Inventory
izoprén (stabilizált) 2-metil-1,3-butadién (hu)
C&L Inventory
izoprēns, stabilizēts 2-metilbutadiēns-1,3 (lv)
C&L Inventory
ισοπρένιο (σταθεροποιημένο) 2-μεθυλο-1,3-βουταδιένιο (el)
C&L Inventory
изопрен (стабилизиран) 2-метил-1,3-бутадиен (bg)
C&L Inventory
1,3-Butadiene, 2-Methyl-
C&L Inventory
1,3-Butadiene, 2-methyl-
C&L Inventory, Registration dossier
2-Methyl-1,3-butadien
C&L Inventory
2-Methyl-1,3-butadiene
C&L Inventory, Registration dossier
2-Methyl-buta-1,3-diene
C&L Inventory
2-methylbuta-1,3-diene
C&L Inventory, Registration dossier, Other
IPM
Registration dossier
Isoprene
C&L Inventory, Registration dossier
Isoprene
C&L Inventory, Registration dossier
isoprene (stabilised)
C&L Inventory
Isoprene (stabilized with TBC)
C&L Inventory
Methyl-1,3-butadiene
C&L Inventory
not appliable
Registration dossier
not applicable
Registration dossier
Butyl Reclaimed Rubber
Registration dossier
IPM
Registration dossier
Isopren
Registration dossier
Isoprene
Registration dossier
Isoprene rubber
Registration dossier
not applicable
Registration dossier
Reclaimed Rubber
Registration dossier
rubber powder
Registration dossier
tire reclaimed rubber
Registration dossier
tread tire reclaim
Registration dossier
whole tire reclaim
Registration dossier
601-014-00-5
Index number
C&L Inventory
78-79-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Ambient Air Quality Directive, Annex X - Ozone Precursor Substances, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
78006-92-5
CAS number
Other
823271-95-0
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Liquid: volatile (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
-145.95 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-145.95 °C

Boiling point

Study results
  • 3 studies submitted
  • 1 study processed
R Boiling point
34.07 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
34 °C

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Relative density
0.68 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.679

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
63.397 - 77.973 kPa @ -2.944 - 21.1 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
63.397 kPa @ 21.1 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
2.58 @ 20 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 1
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
2.42 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
642 mg/L @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
642 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 3 studies submitted
  • 1 study processed
R Flash point
-54 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-54 °C

Auto flammability

Study results
  • 3 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
395 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
395 °C

Flammability

Study results
  • 4 studies submitted
  • 1 study processed
C Interpretation of results
Extremely flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R Other:
0.21 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.21 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 4 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
3.8 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
3.8 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1 3
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 1 study processed
R log Koc
2.1 dimensionless [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
125.893

Henrys law constant (H)

Study results
  • 4 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
2 815 - 77 700 Pa m³/mol @ 25 °C and 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
2 815 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 40.2 - 108 µg/L (2)
Intermittent releases (freshwater) 57.7 µg/L (2)
Marine water 4.02 - 10.8 µg/L (2)
Intermittent releases (marine water) 5.77 µg/L (1)
Sewage treatment plant (STP) 200 µg/L (2)
Sediment (freshwater) 767 - 1 750 µg/kg sediment dw (2)
Sediment (marine water) 76.7 - 175 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 286 - 553 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 9 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 7.43 - 16.854 mg/L [2]
LL50 (72 h) 17.158 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 1 2
Other 4
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (32 days) 1.08 mg/L [1]
NOELR (21 days) 3.287 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 5.77 mg/L [1]
LC50 (48 h) 10.097 mg/L [1]
LL50 (48 h) 32.098 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 2 1
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOELR (21 days) 6.149 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1 2
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 8 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 9.386 mg/L [1]
EC50 (72 h) 15.3 - 35.2 mg/L [2]
NOEC (72 h) 1.68 - 6 mg/L [2]
EL50 (72 h) 17.761 mg/L [1]
NOELR (72 h) 3.403 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 1 4
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
17.761 mg/L
EC10 or NOEC for freshwater algae
3.403 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (5 days) 2 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
2 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
58.525 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
11.212 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 103.1 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
57.465 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
11.009 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
other: (28 days) 6.191 - 32.315 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
32.315 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
6.191 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
95.368 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
18.27 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.4 mg/m³ -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 40 mg/kg bw/day -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2 mg/m³ -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9.5 mg/kg bw/day -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 200 µg/kg bw/day -
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1 1
Supporting study 14
Weight of evidence
Other 7
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Dermal: 0.3 %
Inhalation: 10 %

Acute toxicity

Study results
oral
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 2 125 mg/kg bw (rat) [1]
M/CInterpretations of results
Category 5 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study 2
Weight of evidence 4
Other
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 3.03 mL/kg bw (rat) [2]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other 1
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Study data: inhalation
  • 12 studies submitted
  • 4 studies processed
P/RResults
NOAEC (rat): 613 - 19 503 mg/m³ air [2]
NOAEC (mouse): 28 - 613 mg/m³ air [2]
LOAEC (rat): 19.503 mg/L air [1]
LOAEC (mouse): 195 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 4
Supporting study 2 2
Weight of evidence
Other 4
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
Adverse effect observed NOAEC 28 mg/m³ (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 1 1 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on developmental toxicity
Inhalation route:
Adverse effect observed LOAEC 780 mg/m³ (subacute, mouse)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant