Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Dichloromethane
  • IUPAC name: dichloromethane
  • Other names
EC / List no.:
200-838-9
CAS no.:
75-09-2
Index number:
602-004-00-3
Molecular formula:
CH2Cl2
SMILES:
ClCCl
InChI:
InChI=1S/CH2Cl2/c2-1-3/h1H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
10
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is suspected of causing cancer.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes serious eye irritation, causes skin irritation and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful if swallowed, is suspected of causing genetic defects, may cause damage to organs through prolonged or repeated exposure and may cause respiratory irritation.

Breakdown of all 2014 C&L notifications submitted to ECHA

Carc. 2 H351 Harmonised Classification
Eye Irrit. 2 H319
Skin Irrit. 2 H315
Acute Tox. 4 H302
Muta. 2 H341
STOT SE 3 H336
STOT RE 2 H373
STOT SE 3 H335
Carc. 2 H350
STOT SE 1 H370
Not Classified
STOT RE 1 H372
Aquatic Chronic 2 H411
Met. Corr. 1 H290
Expl. 1.1 H200
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • M
  • R
  • Ss
  • Sr

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 17 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, biocides (e.g. disinfectants, pest control products), coating products, plant protection products, washing & cleaning products and cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: washing & cleaning products, coating products, adhesives and sealants, biocides (e.g. disinfectants, pest control products), plant protection products and cosmetics and personal care products.

This substance is used in the following areas: scientific research and development and agriculture, forestry and fishing.

This substance is used in the following activities or processes at workplace: roller or brushing applications, non-industrial spraying, transfer of chemicals, laboratory work and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: adhesives and sealants and coating products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: washing & cleaning products, extraction agents, adhesives and sealants, coating products and heat transfer fluids. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: chemicals, textile, leather or fur, rubber products, plastic products, mineral products (e.g. plasters, cement), machinery and vehicles and furniture.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals, roller or brushing applications, industrial spraying, laboratory work and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; use only outdoors or in a well-ventilated area; obtain special instructions before use; use personal protective equipment as required.; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Take off contaminated clothing and wash before reuse. Call a poison center or doctor/physician if you feel unwell. If exposed or concerned: get medical advice/attention. If skin irritation occurs: Get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If eye irritation persists get medical advice/attention. If on skin: wash with soap and water. Follow specific treatment (see label).

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • Avantor Performance Materials Poland S.A., Sowińskiego 11 44-100 Gliwice Poland
  • Banner Chemicals Ltd, Sutton Quays Business Park Clifton Road WA7 3EH Runcorn Cheshire United Kingdom
  • Blue Cube Germany Assets GmbH & Co. KG, Buetzflether Sand 2 21683 Stade Germany
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Strasse 40 D-30926 Seelze Lower Saxony Germany
  • INOVYN France S.A.S., Avenue de la République 39500 Tavaux France
  • INOVYN Produzione Italia S.p.A, VIA PIAVE, 6 57013 ROSIGNANO SOLVAY LIVORNO Italy
  • Kem One, IMMEUBLE LE QUADRILLE 19 RUE JACQUELINE AURIOL 69008 LYON France
  • knoell Germany – OR – A1, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • LORD Germany GMBH, Ottostrasse 28 41836 Hueckelhoven North Rhine - Westphalia Germany
  • Merck KGaA, Frankfurter Strasse 64293 Darmstadt Germany
  • Nouryon Industrial Chemicals GmbH, Hauptstraße 47 49462 Ibbenbüren Germany
  • Sigma-Aldrich Biochemie GmbH, Georg-Heyken-Str. 14 21147 Hamburg Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom
  • SpetsInterProject Oy_Khim, Näkinkaari 1 M 02320 Espoo Finland
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Ecotoxward Ltd, 381-383 City Road EC1V 1NW London United Kingdom
  • INOVYN Chlorvinyls Limited, PO Box 9 WA7 4JE Runcorn United Kingdom

Other names

  • -
  • Dichlormethan
  • Dichlormethane
  • DICHLOROMETHANE
  • Dichloromethane (stabilized with 2-Methyl-2-butene)
  • dichloromethane, methylene chloride
  • dichloromethane;
  • Dichloromethane; Methylene Chloride
  • dichlorormethane
  • diclorometano
  • Dischloromethane
  • Methane, dichloro-
  • METHYLENE CHLORIDE
  • Methylene chloride, Dichloromethane
  • Dichloromethane
  • methylene chloride
  • chlorure de methylene
  • dichloromethane
  • MEC Prime
  • MECTHENE MC
  • MECTHENE PU
  • Methoklone
  • Methylene chloride
  • Methylene Chloride SVG
  • Methylene Chloride Technical
  • methylene chloride

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Other (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-95 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-95.15 °C

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
40 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
39.85 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Density
1.33 g/cm³ @ 20 °C [1]
R Relative density
1.33 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Relative density at 20°C
1 320

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
58.4 kPa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Vapour pressure
58.4 kPa @ 25 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Log Pow
1.25 - 1.34 @ 20 °C and pH 7 [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Log Kow (Log Pow)
1.25 @ 20 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
13.2 g/L @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Water solubility
13.2 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
605 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
604.85 °C

Flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.42 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.42 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 6 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
79.31 days [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half life in air
3.567 months

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life for hydrolysis
1.5 years @ 24.85 °C

Phototransformation in water

Study results
  • 4 studies submitted
  • 1 study processed
R Dissipation Half-life (DT50)
1.734 years [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 27 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 23 2
Weight of evidence 1
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater
10.9 days @ 25 °C

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
14.2 days @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
46.8

Henrys law constant (H)

Study results
  • 4 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
116.524 - 330.32 Pa m³/mol @ 9.6 - 34.6 °C [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Henry's law constant
222 Pa.m³.mol-1 @ 24.8 °C

Distribution modelling

Study results
  • 6 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 43.8 % [1]
R Water 45 % [1]
R Soil 11 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence 1
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 130 - 310 µg/L (2)
Intermittent releases (freshwater) 270 µg/L (1)
Marine water 31 - 130 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 26 mg/L (1)
Sediment (freshwater) 163 - 2 570 µg/kg sediment dw (2)
Sediment (marine water) 163 - 260 µg/kg sediment dw (2)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 173 - 330 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning -

Short–term toxicity to fish

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 193 mg/L [1]
LC50 (48 h) 97 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence 1
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
193 mg/L
LC50 for marine water fish
97 mg/L

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 83 - 321 mg/L [3]
NOEC (8 days) 357 mg/L [1]
LC50 (8 days) 471 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
83 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
LC50 (48 h) 27 - 109 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
27 mg/L
EC50 / LC50 for marine invertebrates
109 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 3 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
550 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (40 min) 2.59 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
2.59 g/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 100 µg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 353 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 706 mg/m³ neurotoxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 12 mg/kg bw/day repeated dose toxicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 88.3 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 353 mg/m³ neurotoxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.82 mg/kg bw/day repeated dose toxicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 60 µg/kg bw/day repeated dose toxicity
Acute /short term: - -
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 5 studies submitted
  • 1 study processed
P/RResults
LC50 (7 h) 49 mg/L air (mouse) [1]
M/CInterpretations of results
Study cannot be used for classification [1]

inhalation
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 4 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]

dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed LC50 49 000 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 9 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 6 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 10 studies submitted
  • 2 studies processed
P/RResults
rat (rat): 6 mg/kg bw/day [1]
NOAEC (rat): 200 ppm [1]

Study data: inhalation
Studies with data
Key study 2
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 6 mg/kg bw/day (chronic, rat)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 695 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: in vivo
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 4 1
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 6 mg/kg bw/day (chronic, rat)
Inhalation route:
Adverse effect observed LOAEC 7 000 mg/m³ (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant