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EC number: 619-596-4 | CAS number: 915095-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Jul 2007 - 16 Oct 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- exception: The test article was characterized for composition and purity. However, it was not done under GMP/GLP. It was not characterized for stability.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- exception: The test article was characterized for composition and purity. However, it was not done under GMP/GLP. It was not characterized for stability.
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
- EC Number:
- 619-596-4
- Cas Number:
- 915095-86-2
- Molecular formula:
- C13 H7 Cl F I O
- IUPAC Name:
- (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST animals
Male and female. Females assigned to the test
were nulliparous and non-pregnant. Rats were obtained from Harlan UK.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% hydroxyethylcellulose (HEC) in deionized water
- Details on oral exposure:
- Each animal was dosed by oral intubation using a stainless-steel ball tipped gavage needle attached to a disposable syringe.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 male and 3 female
- Control animals:
- no
- Details on study design:
- All animals were observed at the beginning and the end of the working day for signs of ill health or overt toxicity.
Results and discussion
- Preliminary study:
- In the study fasted rats were given the test article as a single dose by oral
gavage at a dose level of 2000 mg/kg.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in the animals at 2000 mg/kg.
- Clinical signs:
- other: No clinical signs were observed in the animals at 2000 mg/kg.
- Gross pathology:
- No visible lesions were observed in any of the animals at 2000 mg/kg at terminal necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified acc. CLP
- Conclusions:
- The test article, BI 10773 Fluorid, was considered to have no significant acute toxic risk in respect
of its acute oral toxicity and did not meet the criteria for classification according to the
Globally Harmonized System of Classification and Labelling of Chemicals (GHS). - Executive summary:
A. Title Acute Oral Toxicity Study of IN 00078280 in the Rat - Acute Toxic Class Method
B. Objective This study was designed to assess the toxicity of IN 00078280 following a single oral dose to the rat. The results of the study are believed to be of value in predicting the likely toxicity in man by the oral route.
C. Methods One group of three female Wistar rats were orally administered IN 00078280 via oral gavage at 2000 mg/kg. Due to the lack of mortality observed in the females at 2000 mg/kg, an additional group of three males was administered the test article at 2000 mg/kg. Mortality checks were made once daily. Clinical observations were recorded at approximately 0.5, 1 and 4 hours post dose (±15 minutes), and daily thereafter through Day 15. Body weights were recorded on Day 1 (fasted) and on Days 8 and 15. A gross necropsy was performed on all animals on Day 15.
D. Results No mortality was observed in any of the animals at 2000 mg/kg. No clinical signs were observed in the animals at 2000 mg/kg. All animals gained weight throughout the study. Necropsy revealed no visible lesions in any of the animals at 2000 mg/kg at terminal necropsy.
E. Conclusion According to the Globally Harmonized Classification System, IN 00078280 administered orally at dose levels of 2000 mg/kg in male and female rats was considered to be a Category 5 test substance with an LD50 ∞ (unclassified).
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