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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
This information is taken from a reliable peer reviewed pulication.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The use of secondary sources of data is acceptable when they are based on a critcal evaluation of peer-reviewed data and a sonsequent slection of a reliable and representative value for the property under investigation. Therefore, although the method used is not known, the value presented here are acceptable as they are from a reliable secondary source of toxiicologies.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-bromo-2-phenylethane
EC Number:
203-130-8
EC Name:
1-bromo-2-phenylethane
Cas Number:
103-63-9
Molecular formula:
C8H9Br
IUPAC Name:
(2-bromoethyl)benzene
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
dihydrogen oxide
Test material form:
liquid
Details on test material:
colourless liquid
Specific details on test material used for the study:
purity 99.5 %
Product No. B6,578-0
Supplier ALdrich

Test animals

Species:
rabbit
Strain:
not specified

Test system

Controls:
not specified
Amount / concentration applied:
0.5 ml/ 100%
Duration of treatment / exposure:
4 hours
Observation period:
1h, 1d, 2d and 3d
Number of animals:
3
Details on study design:
Not available

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 1h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 1h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 1h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 1h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 1h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 1h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritant / corrosive response data:
Primary Irritation Index = 0
Primary Irritaion idex is defined as follow;
Primary irritation index = (sum erythema 24/48/72 hr + sum edema 24/48/72hr)/(3 x no of animals)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
(2-Bromoethyl)benzene is not irritant to skin within this experiment.
Executive summary:

(2-Bromoethyl)benzene is not irritant to skin within this experiment.