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EC number: 214-968-9 | CAS number: 1229-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute Toxicity Evaluation of Solvent Red 1
- Author:
- Gunda Reddy and Dale A. Mayhew
- Year:
- 1 996
- Bibliographic source:
- International Journal of Toxicology Vol 15, Issue 1_suppl, pp. S43 - S44, 1996
- Reference Type:
- secondary source
- Title:
- Dermal, Eye and Oral toxicological evaluations, phase IV report with Disperse Red 11, Disperse Blue 3, Solvent Red 1 and Red and Violet Mixtures.
- Author:
- U.S. Army Medical Bioengineering Research and development Laboratory
- Year:
- 1 986
- Bibliographic source:
- NTRL- April - 1986, Page no 1-169.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of Solvent Red 1 in New Zealand White rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-[(2-methoxyphenyl)azo]-2-naphthol
- EC Number:
- 214-968-9
- EC Name:
- 1-[(2-methoxyphenyl)azo]-2-naphthol
- Cas Number:
- 1229-55-6
- Molecular formula:
- C17H14N2O2
- IUPAC Name:
- 1-[(2-methoxyphenyl)azo]-2-naphthol
- Test material form:
- solid
- Details on test material:
- - Name of test material : 1-[(2-methoxyphenyl)diazenyl]-2-naphthol
- Common Name: Solvent Red 1
- Molecular formula : C17H14N2O2
- Molecular weight : 278.31 g/mol
- Smiles notation : c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type:Organic
- Physical state:Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1-[(2-methoxyphenyl)diazenyl]-2-naphthol
- Common Name: Solvent Red 1
- Molecular formula: C17H14N2O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Sex: Male and female
- Source: Kuiper’s rabbit ranch, Gary, IN.
- Age at study initiation: No data available
- Weight at study initiation: 2.26 – 2.88 kg
- Fasting period before study: No data available
- Housing: Animals were housed in the appropriate randomly selected cage. Each animal was then assigned a sequential animal number unique within American Biogenics Corporation (ABC) and identified with an ear tag bearing this animal number, The sequential animal number was listed on a cage card that was affixed to the front of the animal's cage. Rooms were cleaned daily and the cages were cleaned and sanitized as specified in ABC SOP's. Urine and feces fell through the wire mesh floor onto animal caging board. The cage boards were changed at least 2 to 3 times per week.
- Diet (e.g. ad libitum): Purina Certified Rodent Chow 5002, ad libitum, except for fasting prior to dosing.
- Water (e.g. ad libitum): Filtered tap water was provided through an automatic watering system and was analyzed periodically, ad libitum.
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 7 °C
- Humidity (%): 30-70 %
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 6:00 a.m. to 6:00 p.m. (12 hour light/dark, cycle)
IN-LIFE DATES: From: October 15, 1985 To: October 29, 1985
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped intact and abraded skin
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- Each rabbit received a dose of 0.5ml Solvent Red 1 on two intact sites and two abraded sites (the right anterior and the left posterior were abraded).
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Sites were scored at 24 and 72 hr. after application
- Number of animals:
- groups of 6 rabbits (3/sex)
- Details on study design:
- TEST SITE
- Area of exposure: Thoracic region of spinal column
- % coverage: No data available
- Type of wrap if used: 2.5 centimeter square gauze patch were used.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Each test site was gently wiped with gauze sponges moistened with an appropriate vehicle (known not to cause any dermal toxic reactions) to remove any remaining test article.
- Time after start of exposure: 24 hours
SCORING SYSTEM: The reactions were scored according to the method of Draize
The Primary Irritation Score was calculated for each test article as follows: the average scores for erythema and eschar formation for intact and abraded skin at 24 (+2) and 72 (+2) hours were added to the average scores for edema for intact and abraded skin at 24 (+2) and 72 (+2) hours. The total of the 16 values was divided by 8 to give the Primary Irritation Score.
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Solvent Red 1 was non-irritating.
Any other information on results incl. tables
Table: Primary Dermal Irritation of Solvent Red 1
Animal Number |
Sex |
Initial Body Weight (kg) |
24(+2) hours**
|
72(+2) hours** |
|||||||||||||||
Intact |
Abraded |
Intact |
Abraded |
||||||||||||||||
Left |
Right |
Left |
Right |
Left |
Right |
Left
|
Right
|
||||||||||||
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
ed |
||||
BB9374 |
Male |
2.56 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9375 |
Male |
2.86 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9422 |
Male |
2.86 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9403 |
Female |
3.10 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9439 |
Female |
2.74 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9449 |
Female |
2.60 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
Total |
|
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Average |
|
|
(A) 0 |
(B) 0 |
(C) 0 |
(D) 0
|
(E) 0 |
(F) 0
|
(G) 0 |
(H) 0 |
(I) 0 |
(J) 0 |
(K) 0 |
(L) 0 |
(M) 0 |
(N) 0 |
(O) 0 |
(P) 0 |
|
**= after test article application
Er= erythema
Ed= edema
R= test site stained red
Primary Irritation Score = (A+B+C+D+E+F+G+H+I+J+K+L+M+N+O+P)/8
Primary Irritation Score = 0.0
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Hence, Solvent Red 1 was considered to be not irritating to rabbit skin.
- Executive summary:
The primary dermal irritation of Solvent Red 1 was assessed in rabbits. The backs of six New Zealand White (NZW) rabbits (three of each sex) were closely clipped 24 hours before dosing. Each rabbit received a dose of 0.5ml Solvent Red 1 on two intact sites and two abraded sites (the right anterior and the left posterior were abraded). After 24 hours of exposure, the wrappings and patches were removed and sites wiped off with gauze sponges moistened with water. Sites were scored at 24 and 72 hours after application using the method of Draize (1979).Each animal was weighed prior to application of each test article. All animals were observed at least once daily for mortality and obvious toxic signs.
No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Hence, Solvent Red 1 was considered to be not irritating to rabbit skin.
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