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EC number: 214-968-9 | CAS number: 1229-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol (CAS no. 1229 -55 -6) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor (2017). Test substance undergoes 29.8% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical
1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment
Biodegradation in water and sediment study was carried out for determining the half-life of test chemical 1-[(2-methoxyphenyl)azo]-2-naphthol (CAS no 1229 -55 -6) under anaerobic conditions (George L. Baughman and Eric J. Weber, 1994). Sediments were obtained from 2 different lakes (i.e, Herrick and Kingfisher) near Athens, GA. The sieved sediment (5-15 cm deep) was stored in the dark, under lake water, in sealed, 2-gal glass or plastic bottles until used.Organic carbon content of sediments was determined at the University of Georgia Soil Testing Laboratory by the Walkley-Black method and by three other combustion methods, including that of Lee and Macalady.Ingeneral, the methods gave comparable results. The percent organic carbon for each lake sediment was as follows: Beef Pond, 3.05 ± 14%(n=9); Herrick, 1.52 :l:56% (n=31); KingfIsher, 7.46:l: 45%(n=10); Oglethorpe, 1.99 :l: 48%(n=7). Sediments were scraped from the top few centimeters of the lake bottom at a water depth of less than about 50 cm and sieved, at the lake, through a 0.5 mm sieve.The desired amount of sediment (based on wet weight and moisture content of filter cake) in lake water was sealed and allowed to remain quiescent for 2-4 days prior to dye addition. During dye addition (in ACN) and mixing, the sediment was maintained under N2 until placement in 20-mL scintillation vials. No attempt was made to measure redox potentials in the compacted sediment of either kinetic or product studies. However, under the study conditions, the reddish Georgia clay sediment quickly became the light gray color that is characteristic of reducing environments.Vials were sacrificed for analysis by shaking, sonicating, and filtering. To a portion of the filter cake was added a volume of ACN equal to twice the sediment moist weight. The vial was then shaken and sonicated and the slurry was filtered.Test chemical was identified by analytical methods such as HPLC and GC. For all kinetic experiments, rate constants for dye loss,kL,were obtained as the slope of a regression of the logarithm of dye concentration versus time.Products of the azo dye, SR 1, were expected to be o-anisidine and l-amino-2-naphthol resulting from reductive cleavage of the azo bond. However, these compounds could not be identified by HPLC because they coeluted. After GPC cleanup, each product was detected by GC-MS with both spectra and retention times identical to those of purchased materials.The half-life value of test chemical 1-[(2-methoxyphenyl)azo]-2-naphthol in sediment obtained from2 different lakes (i.e, Herrick and Kingfisher) was determined to be 4.0 and 2.2 days with an average first order rate constant of 7.2 × 10-3and 1.3 × 10-2, respectively. Based on this half-life value, it indicates that 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol is not persistent in sediment.
Biodegradation in soil
The half-life period of 1-[(2-methoxyphenyl)diazenyl]-2-naphthol (CAS No. 1229 -55 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.9% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1-[(2-methoxyphenyl)diazenyl]-2-naphthol in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of
1-[(2-methoxyphenyl)diazenyl]-2-naphthol, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various predicted data for the target compound 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol(CAS No. 1229 -55 -6) and supporting weight of evidence study for its closest read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical1-[(2-methoxyphenyl)diazenyl]-2-naphthol(CAS No. 1229-55-6) was estimated.Test substance undergoes 29.8% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol was estimated to be not readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol(CAS No. 1229 -55 -6) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol is expected to be not readily biodegradable.
In a supporting weight of evidence study for the read across chemical 1-(phenyldiazenyl)-2-naphthol (CAS no. 842-07-9), the carbon dioxide evolution test (former Sturm test) is a static method used for evaluating the ultimate aerobic biodegradability of a read across substance 1-(phenyldiazenyl)-2-naphthol in water (Sustainability Support Services (Europe) AB has letter of access, 2003). Activated sludge was obtained from laboratory wastewater plant treating municipal sewage. Activated sludge of a concentration of 30 mg/I dry substance was pre-aerated for about two days before the start of the test. Mixtures of the test substance, a defined inorganic medium and a non pre-adapted inoculurn (e .g. activated sludge or effluent of a municipal or laboratory waste water treatment plant) are incubated and aerated at room temperature up to 28 days. The biologically produced carbon dioxide is trapped in a 0,25 mol. potassium hydroxide solution. The production of carbon dioxide (C02) is a clear indication of biodegradation. The measured amount of carbon dioxide at the end of the test is compared with the calculated maximal theoretical production (ThC02) and indicated as biodegradation degree in percent. The conductivity shift of the absorption solution is used for calculating of the C02 production. Biodegradation degree of the reference substance after 14 days (% CO2/ThCO2): 60 - 70%. The percentage degradation of the read across substance was determined to be <10% in 28 days by CO2/ThCO2 parameter. Thus, the substance 1 -(phenyldiazenyl)-2 -naphthol is considered to be not readily biodegradable according to OECD criteria.
On the basis of above results for target chemical1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from experimental report), it can be concluded that the test substance 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Biodegradation in water and sediment study was carried out for determining the half-life of test chemical 1-[(2-methoxyphenyl)azo]-2-naphthol (CAS no 1229 -55 -6) under anaerobic conditions (George L. Baughman and Eric J. Weber, 1994). Sediments were obtained from 2 different lakes (i.e, Herrick and Kingfisher) near Athens, GA. The sieved sediment (5-15 cm deep) was stored in the dark, under lake water, in sealed, 2-gal glass or plastic bottles until used.Organic carbon content of sediments was determined at the University of Georgia Soil Testing Laboratory by the Walkley-Black method and by three other combustion methods, including that of Lee and Macalady.Ingeneral, the methods gave comparable results. The percent organic carbon for each lake sediment was as follows: Beef Pond, 3.05 ± 14%(n=9); Herrick, 1.52 :l:56% (n=31); KingfIsher, 7.46:l: 45%(n=10); Oglethorpe, 1.99 :l: 48%(n=7). Sediments were scraped from the top few centimeters of the lake bottom at a water depth of less than about 50 cm and sieved, at the lake, through a 0.5 mm sieve.The desired amount of sediment (based on wet weight and moisture content of filter cake) in lake water was sealed and allowed to remain quiescent for 2-4 days prior to dye addition. During dye addition (in ACN) and mixing, the sediment was maintained under N2 until placement in 20-mL scintillation vials. No attempt was made to measure redox potentials in the compacted sediment of either kinetic or product studies. However, under the study conditions, the reddish Georgia clay sediment quickly became the light gray color that is characteristic of reducing environments.Vials were sacrificed for analysis by shaking, sonicating, and filtering. To a portion of the filter cake was added a volume of ACN equal to twice the sediment moist weight. The vial was then shaken and sonicated and the slurry was filtered.Test chemical was identified by analytical methods such as HPLC and GC. For all kinetic experiments, rate constants for dye loss,kL,were obtained as the slope of a regression of the logarithm of dye concentration versus time.Products of the azo dye, SR 1, were expected to be o-anisidine and l-amino-2-naphthol resulting from reductive cleavage of the azo bond. However, these compounds could not be identified by HPLC because they coeluted. After GPC cleanup, each product was detected by GC-MS with both spectra and retention times identical to those of purchased materials.The half-life value of test chemical 1-[(2-methoxyphenyl)azo]-2-naphthol in sediment obtained from2 different lakes (i.e, Herrick and Kingfisher) was determined to be 4.0 and 2.2 days with an average first order rate constant of 7.2 × 10-3and 1.3 × 10-2, respectively. Based on this half-life value, it indicates that 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol is not persistent in sediment.
Biodegradation in soil
The half-life period of 1-[(2-methoxyphenyl)diazenyl]-2-naphthol (CAS No. 1229 -55 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.9% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1-[(2-methoxyphenyl)diazenyl]-2-naphthol in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of
1-[(2-methoxyphenyl)diazenyl]-2-naphthol, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance 1 -[(2 -methoxyphenyl)diazenyl]-2 -naphthol can be considered to be not readily biodegradable in nature.
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