Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
5 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

Based on the composition of the substance and the lack of bioavailability, the acute toxicity after oral and dermal exposure can be estimated as higher than 2,000 mg/kg.

 

The inhalation exposure of rats to comparable "SPINEL" at the maximal technically feasible concentration of 3.5 mg/L did not produce signs of toxicity. All animals survived and no adverse effects were observed during the 14-day observation period. Histologically rests of the test substance and borderline signs of tissue damage were seen.

 

With respect to inhalation toxicity LC50of "SPINEL" for male and female rats is therefore greater than 3.5 mg per litre air which is the highest technically feasible dust concentration.

 

Due to lack any signs of toxicity at 3.5 mg/L, LC50of "SPINEL" after inhalation is considered to be higher than 5 mg/l, which represents the limit for classification the substance as toxic.

 

Applying read-across it can be assumed that the LC50 for acute inhalation of Pleonaste is also greater than 5 mg/L and the substance can also be classified as practically non-toxic.