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Diss Factsheets
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EC number: 200-018-0 | CAS number: 50-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1934
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of feeding sodium bicarbonate or lactic acid upon the sex ratio in rats
- Author:
- D'Amour F.E.
- Year:
- 1 934
- Bibliographic source:
- Science 79 (2038), 61-62
Materials and methods
Test material
- Reference substance name:
- Lactic acid
- EC Number:
- 200-018-0
- EC Name:
- Lactic acid
- Cas Number:
- 50-21-5
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-hydroxypropanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- Animals to be bred were placed on stock diet, which consists of a mixture of ground grains, dried milk, mineral salts and cod liver oil, with which was incorporated with either sodium bicarbonate or lactic acid.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Prior to breeding to parturition
Doses / concentrationsopen allclose all
- Dose / conc.:
- 2.5 other: %
- Remarks:
- Percent of lactic acid in stock diet
- Dose / conc.:
- 5 other: %
- Remarks:
- Percent of lactic acid in stock diet
Results and discussion
Any other information on results incl. tables
Concentration |
# litters | Males | Females | Total |
2.5% lactic acid in feed | 10 | 38 | 42 | 80 |
5% lactic acid in feed | 28 | 107 | 128 | 235 |
Total | 38 | 145 | 170 | 315 |
Sex ratio (females/males) = 170 /145 = 1.17
Applicant's summary and conclusion
- Conclusions:
- The sex ratio of the offspring was not affected by the treatment with lactic acid.
- Executive summary:
The sex ratio of the offspring was not affected by the treatment with lactic acid.
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