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Diss Factsheets
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EC number: 203-744-6 | CAS number: 110-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A theoretical assessment of the toxicokinetic properties of TMEDA is provided.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Absorption
TMEDA is of low molecular weight (Mw 116) and is miscible with water; these properties will favour oral absorption. TMEDA is also predicted to be orally bioavailable according to Lipinski's rules (OECD Toolbox: OASIS). The results of the OECD 422 screening study with TMEDA indicate systemic toxicity consistent with oral bioavailability. In the absence of data on dermal and inhalation absorption, default assumptions are made. The physicochemical properties of TMEDA indicate that dermal absorption is likely; it is also noted that TMEDA is corrosive to skin and may therefore affect the integrity of the skin as a barrier to absorption.
Distribution
The results of the OECD 422 screening study indicate distribution to the liver (increased AST activity) and also post-hepatic systemic distribution (haematological effects).
Metabolism
OECD Toolbox metabolism simulators indicate that TMEDA is likely to be metabolised in the liver through a combination of N-demethylation and oxidative reactions to produce small water-soluble metabolites. A total of 8 metabolites are predicted, some of which may be incorporated into normal metabolism.
Excretion
TMEDA is a small, highly water-soluble molecule and is therefore likely to be subject to renal excretion. The predicted metabolites of TMEDA are also small and water soluble and similarly likely to be subject to renal excretion. Biliary excretion is not predicted.
Bioaccumulation
Based on its physicochemical properties and predicted metabolism, bioaccumulation is considered to be unlikely. However it is noted that some of the predicted metabolites of TMEDA may be incorporated into normal metabolism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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