Registration Dossier
Registration Dossier
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EC number: 807-935-0 | CAS number: 1244733-77-4
Bioaccumulation: terrestrial
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation: terrestrial
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The method of Jager is used for estimating the BCF value in earthworms based on logKow.
Jager ,1998: Mechanistic approach for estimating bioconcentration of organic chemicals in earthworms (Oligochaeta). Environmental Toxicology and Chemistry, 17(10), 2080-2090. - GLP compliance:
- no
- Specific details on test material used for the study:
- Calculation relates to pure substance.
- Test organisms (species):
- other: earthworm
- Type:
- BCF
- Value:
- 6.58
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of TCPP for the terrestrial compartment was calculated using a QSAR-model of Jager (1998). On the basis of the logKow of 2.68, a BCFearthworm of 6.58 was estimated, indicating no potential on bioaccumulation in terrestrial organisms.
- Executive summary:
On the basis of the logKow of 2.68, a BCFearthworm of 6.58 was estimated for TCPP.
A QSAR model was used for estimating the BCF value in earthworms based on log Kow. As recommended in the Guidance document on information requirements and chemical safety assessment R.7c, the model of Jager (1998) is used as a reasonable worst case assumption for an initial assessment.
Reference
The BCF ist estimated as follows:
BCFearthworm = (0.84 + 0.012 Kow) / RHOearthworm
where:
-for RHOearthworm by default a value of 1 kgwwt. L-1 can be assumed
-the log Kow for TCPP is 2.68 ± 0.36
On the basis of the uncertainty on this value, a range of BCF can be estimated. From the above equation, a BCFearthworm = 6.58 (range 3.35 - 14.0) is estimated.
Description of key information
The BCF of TCPP for the terrestrial compartment was calculated using a QSAR-model of Jager (1998). On the basis of the logKow of 2.68, a BCFearthworm of 6.58 was estimated, indicating no potential on bioaccumulation in terrestrial organisms.
Key value for chemical safety assessment
- BCF (terrestrial species):
- 6.58 dimensionless
Additional information
For TCPP no experimental data on the bioaccumulation potential for the terrestrial compartment are available.
On the basis of the logKow of 2.68, a BCFearthworm of 6.58 is estimated for TCPP.
A QSAR model was used for estimating the BCF value in earthworms based on log Kow. As recommended in the Guidance document on information requirements and chemical safety assessment R.7c, the model of Jager (1998) is used as a reasonable worst case assumption for an initial assessment.
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