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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
The protective roles of vitamins A and D against excess intake of boric acid in vivo.
Author:
Geyikoglu F, Turkez H, Topal A, Keles MS & Ozkan A
Year:
2006
Bibliographic source:
Proceedings of 3rd International Boron Symposium 02-04 November 2006, Ankara.

Materials and methods

Type of study / information:
The intraperitoneal effects of different boric acid concentrations were assessed.
Test guideline
Qualifier:
according to
Guideline:
other: No data
Deviations:
not specified
Principles of method if other than guideline:
The intraperitoneal effects of different boric acid concentrations on concentrations of serum enzymes, haematological parameters and liver histology were assessed.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Boric acid

Results and discussion

Applicant's summary and conclusion

Conclusions:
Haematological parameters slightly decreased with exposure to 750 mg/kg boric acid at 48 h but all values were not significantly different from controls. LDH and hepatocytes were unchanged. At low doses of boric acid levels of ALT, ALP and LDH as AST were unsignificantly decreased at 48 h.