Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-219-0 | CAS number: 15174-47-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline or method detailed in report.
- GLP compliance:
- no
- Remarks:
- Pre-GLP study.
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- (E)-2-methyl-3-phenylprop-2-enal
- Cas Number:
- 15174-47-7
- IUPAC Name:
- (E)-2-methyl-3-phenylprop-2-enal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Test material was described with the generic name "alpha-methylcinnamaldehyde". As manufactured by Innospec, the product met the criteria of > 80% trans-isomer, supporting that the test material was the isomer better described as CAS 15174-47-7.
Compound No.: RIFM 72-257
Clear liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Not specified
- Duration of exposure:
- Not specified
- Doses:
- 5 gm/Kg bw
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 5000 mg/Kg bw
Any other information on results incl. tables
Table 1. Distribution of Mortality |
|||||||||||||||
Dose (g/Kg) |
Observation Day |
Mortality |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
5.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
- Conclusions:
- The acute dermal LD50 of Alpha methyl cinnamic aldehyde was determined to be >5000 mg/Kg.
- Executive summary:
In a key acute dermal toxicity study, the test material (Alpha methyl cinnamic aldehyde) was dermally administered to rabbits (10/dose) at a dose of 5000 mg/kg (5 g/kg).
No mortality was observed through the study period.
The acute dermal LD50 of Alpha methyl cinnamic aldehyde was therefore determined to be >5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
