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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September - October 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
TEST MATERIAL
- Substance identification/name in the report: LZ 596
- Molecular formula: C21H30N2
- Batch no.: 1229
- Analysis date: August 12, 2014
- Date of production: August 11, 2014

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from light and humidity.
- Stability under test conditions: stable for min. 3 years from manufacturing date
- Expiry date: August 10, 2017
- Safety precautions: Routine safety precautions (lab coat, gloves, safety glasses, face mask) for unknown materials were applied to assure personnel health and safety.
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.4
Temp.:
25 °C
Remarks on result:
other: pH not measured
Conclusions:
The partition coefficient n-octabol/water was determined to be log Pow = 4.4 at 25°C.
Executive summary:

The study was carried out according to EC method A.8, using the HPLC method. The partition coefficient n-octanol/water was calculated based on the calibration data obtained with the reference substances and found to be log Pow = 4.4 at 25°C.

Description of key information

The study was carried out according to EC method A.8, using the HPLC method. The partition coefficient n-octanol/water was calculated based on the calibration data obtained with the reference substances and found to be log Pow = 4.4 at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
4.4
at the temperature of:
25 °C

Additional information

Source: GLP-report