Registration Dossier
Registration Dossier
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EC number: 203-628-5 | CAS number: 108-90-7
Monitoring data
Administrative data
- Endpoint:
- monitoring data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scietifically accpetable publication, basic data given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Biological monitoring of exposure to monochlorobenzene
- Author:
- KustersE. and Lauwerys R.
- Year:
- 1 990
- Bibliographic source:
- Int. Arch. Occup. Environ. Health 62: 329-331
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The concentration of the substance was determined with HPLC.
- GLP compliance:
- no
- Media:
- air
Test material
- Reference substance name:
- Chlorobenzene
- EC Number:
- 203-628-5
- EC Name:
- Chlorobenzene
- Cas Number:
- 108-90-7
- Molecular formula:
- C6H5Cl
- IUPAC Name:
- chlorobenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): chlorobenzene
- Analytical purity: No data
Constituent 1
Results and discussion
Concentrationopen allclose all
- Country:
- not specified
- Location:
- concentration at contaminated site (industry)
- Substance or metabolite:
- substance
- Conc.:
- 1.2 ppm
- Country:
- not specified
- Location:
- industry workers
- Substance or metabolite:
- metabolite
- Remarks:
- 4-chlorophenol in urine
- Conc.:
- 1.4 other: mg/g
- Country:
- not specified
- Location:
- industry workers
- Substance or metabolite:
- metabolite
- Remarks:
- 4- chlorocatechol in urine
- Conc.:
- 3.3 other: mg/g
Any other information on results incl. tables
| Results |
Environmental Monitoring |
Biological monitoring |
|
| Monochlorobenzene in air (ppm) |
4-chlorophenol in urine (mg/g create) |
4- chlorocatechol in urine (mg/g create) |
|
| Median |
1.2 |
1.4 |
3.3 |
| Range |
< 0.05 - 106 | < 0.2 ¿ 21.1 | < 0.2 ¿ 57.9 |
The followed up of 21 workers during several consecutiv edays showed that more than 80 % of the metabolites excreted in urine are eliminated within 16 hours after the end of exposurean dno tendency for increased concentrations of the metabolites in the preshift urine samples during the workweek could be proven.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
