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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Inhalation Toxicology of Urban Ambient Particulate Matter: Acute Cardiovascular Effects in Rats.
Author:
Vincent R et al
Year:
2001
Bibliographic source:
Research Report no. 104: Inhalation Toxicology of Urban Ambient Particulate Matter: Acute Cardiovascular Effects in Rats. Health Effects Institute. October 2001.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: pellets

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose only
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 4 - <= 4 h
Concentrations:
4.6 mg/m3
Control animals:
not specified

Results and discussion

Preliminary study:
LC0 (4-hour)=4.6 mg/m3
no mortality, no signs of acute toxicity were observed
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
>= 4.6 - <= 4.6 mg/m³ air
Based on:
not specified
95% CL:
>= 0 - <= 0
Exp. duration:
4 h
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
no mortality
Clinical signs:
other: no clinical signs

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information
Conclusions:
Carbon black is not classified as acute inhalation toxicant.
Executive summary:

no detected mortality or signs of toxicity