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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical observation
Adequacy of study:
other information
Study period:
before 1980
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient detail reported, carbon black not specified further

Data source

Reference
Reference Type:
publication
Title:
Problems arising from the use of cosmetics on the lid margin [in German]
Author:
Haddad R, Zehetbauer G
Year:
1980
Bibliographic source:
Klin. Mbl. Augenheilk. 177, 829-831 (in German with English abstract)

Materials and methods

Study type:
clinical case study
Endpoint addressed:
eye irritation

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
general
Subjects:
6 female patients of an eye clinic
Route of exposure:
ocular
Reason of exposure:
intentional

Results and discussion

Clinical signs:
This paper reports on clinical and histopathological changes of the  conjuctiva after long-term use of cosmetics containing carbon black (mascara, eyeliner) on the lid margin. 
Penetration of tiny pigmented particles into the stroma of the conjuctiva initially causes a follicular reaction and later results in a chronic follicular-papillary reaction. There were no signs of an allergic reaction.
Results of examinations:
Clinical and histopathological changes of the conjunctiva were found in 6 female patients of an eye clinic after long-term application on the eye lid of cosmetics containing carbon black (mascara, eyeliner). 
Penetration of tiny pigmented particles into the stroma of the conjuctiva initially causes a follicular reaction and later resulted in a chronic follicular-papillary reaction. There were no signs of an allergic reaction.
Effectivity of medical treatment:
No medical treatment reported.
Outcome of incidence:
not reported.

Applicant's summary and conclusion

Conclusions:
This paper reports on clinical and histopathological changes of the  conjuctiva after long-term use of cosmetics containing carbon black (mascara, eyeliner) on the lid margin. Penetration of tiny pigmented particles into the stroma of the conjuctiva initially causes a follicular reaction which is evidently toxic, and later, results in a chronic follicular-papillary reaction.