Registration Dossier
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EC number: 204-881-4 | CAS number: 128-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- other: review
- Rationale for reliability incl. deficiencies:
- other: review
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Teport for 14th SIAM (Paris, France, Narch 2002)
- Author:
- SIDS Initial Assessment Report
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Teport for 14th SIAM (Paris, France, Narch 2002)
Materials and methods
- Principles of method if other than guideline:
- other: review
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Results and discussion
Main ADME results
- Type:
- other:
- Results:
- SIDS Initial Assessment Report on BHT
Any other information on results incl. tables
As described by the SIDS Initial Assessment Report (text taken from SIDS Initial Assessment Report without change): BHT is readily absorbed through the gastrointestinal tract and, to a small extent, through the intact skin. After long-term feeding of BHT-containing diets the compound is accumulated especially in adipose tissue, while lower levels are found in the liver, with elimination half-lives of 7 to 10 days for both organs on cessation of treatment. In rats and probably also in humans, an enterohepatic circulation takes place, particularly for the metabolite BHT acid and its glucuronide. BHT is excreted primarily in the urine and, to a smaller extent, in the faeces. After a single oral application to rats 80 to 90 % of the dose was found in the urine within four days, most of it within 24 hours. Rabbits excrete approximately 54% within four days and humans 66% within 11 days in urine. Several metabolic pathways and metabolites have been identified. BHT is activated by cytochrome P450 dependent metabolic reaction in the liver.
Applicant's summary and conclusion
- Executive summary:
As discussed and concluded in the SIDS Initial Assessment Report on BHT, BHT is readily absorbed through the gastrointestinal tract and, to a small extent, through the intact skin. After long-term feeding of BHT-containing diets the compound is found especially in adipose tissue, while lower levels are found in the liver, with elimination half-lives of 7 to 10 days for both organs on cessation of treatment. In rats and probably also in humans, an enterohepatic circulation takes place, particularly for the metabolite BHT acid and its glucuronide. BHT is excreted primarily in the urine and, to a smaller extent, in the faeces. After a single oral application to rats 80 to 90 % of the dose was found in the urine within four days, most of it within 24 hours. Rabbits excrete approximately 54% within four days and humans 66% within 11 days in urine. Several metabolic pathways and metabolites have been identified. BHT is activated by cytochrome P450 dependent metabolic reaction in the liver (SIDS 2002).
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