2,6-di-tert-butyl-p-cresol

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

other: review

Rationale for reliability incl. deficiencies:

other: review

Data source

Reference

Reference Type:

review article or handbook

Title:

SIDS Initial Assessment Teport for 14th SIAM (Paris, France, Narch 2002)

Author:

SIDS Initial Assessment Report

Year:

2002

Bibliographic source:

SIDS Initial Assessment Teport for 14th SIAM (Paris, France, Narch 2002)

Materials and methods

Principles of method if other than guideline:

other: review

GLP compliance:

not specified

Test material

Reference

Name:

Unnamed

Type:

Constituent

Results and discussion

Main ADME results

Type:

other:

Results:

SIDS Initial Assessment Report on BHT

Any other information on results incl. tables

As described by the SIDS Initial Assessment Report (text taken from SIDS Initial Assessment Report without change): BHT is readily absorbed through the gastrointestinal tract and, to a small extent, through the intact skin. After long-term feeding of BHT-containing diets the compound is accumulated especially in adipose tissue, while lower levels are found in the liver, with elimination half-lives of 7 to 10 days for both organs on cessation of treatment. In rats and probably also in humans, an enterohepatic circulation takes place, particularly for the metabolite BHT acid and its glucuronide. BHT is excreted primarily in the urine and, to a smaller extent, in the faeces. After a single oral application to rats 80 to 90 % of the dose was found in the urine within four days, most of it within 24 hours. Rabbits excrete approximately 54% within four days and humans 66% within 11 days in urine. Several metabolic pathways and metabolites have been identified. BHT is activated by cytochrome P450 dependent metabolic reaction in the liver.

Applicant's summary and conclusion

Executive summary:

As discussed and concluded in the SIDS Initial Assessment Report on BHT, BHT is readily absorbed through the gastrointestinal tract and, to a small extent, through the intact skin. After long-term feeding of BHT-containing diets the compound is found especially in adipose tissue, while lower levels are found in the liver, with elimination half-lives of 7 to 10 days for both organs on cessation of treatment. In rats and probably also in humans, an enterohepatic circulation takes place, particularly for the metabolite BHT acid and its glucuronide. BHT is excreted primarily in the urine and, to a smaller extent, in the faeces. After a single oral application to rats 80 to 90 % of the dose was found in the urine within four days, most of it within 24 hours. Rabbits excrete approximately 54% within four days and humans 66% within 11 days in urine. Several metabolic pathways and metabolites have been identified. BHT is activated by cytochrome P450 dependent metabolic reaction in the liver (SIDS 2002).