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EC number: 204-881-4
CAS number: 128-37-0
At this high concentration (22
mg/L) the stimulation of the endocrine receptor (ER) was, however, less
than 15 % of the maximum response obtained with 17ß-estradiol. It is
reported that BHT did not “impair binding of tritiated estradiol to the
ER”. Thus, there was no proof for an interaction of BHT with the ER
Jobling et al. used a fish
endocrine receptor (ER) binding assay with Oncorhynchus mykiss cells.
The initial screening process was carried out using a cytosolic extract
from the liver. No stimulation of the receptor activity was determined
for BHT until concentrations exceeded a concentration of 1*10-4
M (22 mg/L). At this high concentration the stimulation of the ER was,
however, less than 15 % of the maximum response obtained with
17ß-estradiol. Jobling et al. additionally reported that BHT did not
“impair binding of tritiated estradiol to the ER”. Thus, there was no
proof for an interaction of BHT with the ER receptor.
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