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Toxicity to aquatic algae and cyanobacteria

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Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF)
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
0.758 mg/L
Remarks on result:
other: The estimated 96-h EC50 for green algae is 0.758 mg/l (ECOSAR v1.00a, phenols class).
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96-h EC50 for green algae is 0.758 mg/l (ECOSAR v1.00a, phenols class).
Executive summary:

The estimated 96-h EC50 for green algae is 0.758 mg/l (ECOSAR v1.00a, phenols class).

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
The tests was conducted based on OECD-GLP standards and OECD test guidelines.
Qualifier:
according to
Guideline:
OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
Deviations:
not specified
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
72 h
Reference substance (positive control):
not specified
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 0.24 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
0.24 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
growth rate
Validity criteria fulfilled:
not specified
Conclusions:
Based on growth rate, the 72h-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72h-NOEC was 0.24 mg/L.
Executive summary:

A growth inhibition test was conducted with the test subtance BHT in Pseudokirchneriella subcapitata according to OECD GLP standards and OECD guideline 201 by the Ministry of the Envinronment in Japan. Based on growth rate, the 72hour-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72hour-NOEC was 0.24 mg/L.

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1999
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
The tests was conducted based on OECD-GLP standards and OECD test guidelines. However, the Ministry of the Environment of Japan suggest confirmation of the results since the test was conducted in 1999 and some of the tests conducted before 2002 were performed using a dispersant.
Qualifier:
according to
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
not specified
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
72 h
Reference substance (positive control):
not specified
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 7 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
1.7 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 10 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: AUG
Remarks:
Area under growth curve
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
1 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: AUG
Remarks:
Area under growth curve
Validity criteria fulfilled:
not specified
Conclusions:
The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate, based on area under growth curve (AUG) the 72hour-EC50 was >10 mg/L and the 72hour-NOEC was 1.0 mg/L
Executive summary:

A growth inhibition test was conducted with the test subtance BHT in Pseudokirchneriella subcapitata according to OECD GLP standards and OECD guideline 201 by the Ministry of the Envinronment in Japan. The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate, based on area under growth curve (AUG) the 72hour-EC50 was >10 mg/L and the 72hour-NOEC was 1.0 mg/L

Description of key information

Estimated data: The estimated 96 -h ECC50 for green algae is 0.758 mg/L (ECOSAR V1.00a. phenol class).

Experimentla results: The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate.

Experimental results: Based on growth rate, the 72h-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72h-NOEC was 0.24 mg/L.

Key value for chemical safety assessment

EC10 or NOEC for freshwater algae:
0.24 mg/L

Additional information

Weight of evidence

Estimated data: The estimated 96 -h EC50 for green algae is 0.758 mg/L (ECOSAR V1.00a. phenol class).

Experimental results: The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate.

Experimental results: Based on growth rate, the 72h-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72h-NOEC was 0.24 mg/L.